Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci

Abstract

Phylogenetic relationship and the population structure of 500 individuals from the Christian community of Lahore, Pakistan, were examined based on 15 autosomal short tandem repeats (STRs) using the AmpFℓSTR Identifiler Plus PCR Amplification Kit and our previously published Y-filer kit data (17 Y-STRs) of same samples. A total of 147 alleles were observed in 15 loci and allele 11 at the TPOX locus was the most frequent with frequency value (0.464). The data revealed that the Christian population has unique genetic characteristics with respect to a few unusual alleles and their frequencies relative to the other Pakistani population. Significant deviations from Hardy–Weinberg equilibrium were found at two loci (D13S317, D18S51) after Boneferroni’s correction (p ≤ 0.003). The combined power of discrimination, combined power of exclusion and cumulative probability of matching were 0.999999999999999978430815060354, 0.999995039393942 and 2.15692 × 10−17, respectively. On the bases of genetic distances, PCA, phylogenetic and structure analysis Lahore-Christians appeared genetically more associated to south Asian particularly Indian populations like Tamil, Karnataka, Kerala and Andhra Pradesh than rest of global populations.

Genomic Insight Into 21 Hypervariable Molecular Markers in The Population of Lower Himalayan Geographical Province Himachal Pradesh, India

“…In the Phylogenetic tree, East Indian, East Asian, and South Indian populations are depicted into the separate branches. This Phylogenetic relationship indicates the similar genetic constituents among the North, North-west, Central India, and West Asia 62,53 . However geographically close North and Northeast populations' viz., Nepalese, Gorkhas, Kathmandu, Tibet, Newar, Tibetan population (Nepal) showed a higher genetic a nity with the East Asian populations viz., Manchu population of China, Korean population, Royal Kingdom of Bhutan Population and Han population of Southern China rather than the population of Himachal Pradesh.…”

A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China

“…Interestingly, Qiang showed a genetic affinity with Tibetans in A-STRs but was not seen in X-STRs. Different results based on the analysis of different chromosomes are also found in other ethnic groups [ 56 , 57 ]. However, it is also possible that this is due to the low number of overlapping X-STRs used, and more Tibetan data are needed to confSequencing of aDNA pirm this phenomenon.…”