Population Genetic Studies in Kerala and the Nilgiris (South West India)

Saha, Nihar Ranjan; Kirk, R.L.; Shanbhag, Shaila; Joshi, Sheloj; Bhatia, H. M.

doi:10.1159/000152802

Cited by 29 publications

(29 citation statements)

References 4 publications

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“…Omoto and Blake (1972) described a similar variant in a Chinese of Singapore. In the present investigation no variant of type 2-1 was found, but there are reports of one example in each of the nontribal groups of Andhra and a frequency of the P G I ~ allele of 1.2~ from Christians of Kerala (Ramesh et al, 1979(Ramesh et al, , 1980Saha et al, 1976). This suggests localisation of the allele to specific populations of south India.…”

Section: A) the P G I 2 Allelecontrasting

confidence: 55%

Population genetic study of red cell enzyme phosphoglucose isomerase in India

Papiha

Chahal

1984

Jap J Human Genet

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SummaryThe distribution of red cell enzyme phosphoglucose isomerase was studied by starch gel electrophoresis in 27 different endogamous groups of India. Forty one electrophoretic variants belonging to four out of the nine known heterozygote types and one rare homozygous variant (PGI-3) were found. Comparison of the results with in India and certain other populations showed that PGI is certainly another useful genetic parameter for the study of population diversity in Asia.Inherited variation of the enzyme phosphoglucose isomerase [PGI; o~-D-glucose 6-phosphate ketol isomerase; EC 5.3.1.9] was initially described by Detter et al. (1968), the enzyme being referred to as phosphohexose isomerase. Since this discovery there have been reports of rare genetically determined variants or variants with low catalytic activities from various populations of the world Fitch et al., 1968;Paglia et al., 1969;Shinoda, 1970; Tariverdian et aI., 1970;Welch 1971;Luan Eng and Welch, 1972;Sanpitak et aL, 1973; Nakashima et aI., 1973;Isacchi et al., 1979), most of which concerns the sporadic occurrence of one or two of the nine heterozygotic types originally described in addition to the usual homozygous phenotype PGI-1. The exceptions are the heterozygous phenotypes PGI 3-1 and 4-1 which are of particular interest in Asiatic populations. In both the studies from London (Detter et al., 1968;Welch, 1971) the Asiatic Indians showed an appreciable frequency of the variant PGI 3-1 and subsequent studies of indigenous samples confirmed that the PGI a allele attains polymorphic frequencies in certain populations of India. Indeed, the relatively high frequency of this allele led to the detection of the homozygous phenotype PGI-3 (Papiha et aL, 1974). Ishimoto and Kuwata (1974) compiled the PGI studies in Japan and showed that in Japanese PGI 4-1 variant is more frequent than the other known heterozygous variants. This relatively high frequency of the PGI 4 allele in Japan consistent with the previous studies of Shinoda (1970), also led to the finding of a rare

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Section: A) the P G I 2 Allelecontrasting

confidence: 55%

Population genetic study of red cell enzyme phosphoglucose isomerase in India

Papiha

Chahal

1984

Jap J Human Genet

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“…Jia et al (2005) reported an extremely low frequency of Pro7 in a Chinese population, although Duan et al (2005) failed to detect this allele in the same region. In our study, the highest frequency of this allele (0.23) was observed in the Kota (haplotype CGG frequency is 0.23) Since the Kota have been a small, isolated population for at least 2,000 years (Breeks 1873;Saha 1976;Roychoudhury et al 2001), the high frequency of Pro7 is likely due to a founder effect or genetic drift. The Pro7 allele is also found in the Siddi, who are a recent migrant group from Africa (haplotype CGG frequency is 0.017).…”

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confidence: 42%

Allelic variation in the NPY gene in 14 Indian populations

et al. 2007

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NPY is a 36-aminoacid peptide expressed in several areas of the nervous system. Neuropeptide Y (NPY) receptors represent a widely diffused system that is involved in the regulation of multiple biological functions. The human NPY gene is located in chromosome 7. The functional significance of coding Leu7Pro polymorphism in the signal peptide of preproNPY is known. Six hundred and fifty four individuals of 14 ethnic Indian populations were screened for three mutations in the NPY gene, including Leu7Pro. We found that the Pro7 frequencies among the studied populations were much higher than in previous studies from other parts of the world. The highest allele frequency of Pro7 was detected in the Kota population in the Nilgiri Hill region of south India, and this may reflect a founder event in the past or genetic drift. All populations followed the Hardy-Weinberg equilibrium for the assayed markers. A total of five haplotypes were observed, only two of which were found to occur with a high frequency in all populations. No linkage disequilibrium (LD) was observed across the tested alleles in any population with the exception of Leu7Pro and Ser50Ser in the Badaga population (v 2 = 13.969; p = 0.0001).

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“…Highest frequency of Cal-1 type has been reported among the Kurumbas of Nilgiri Hill (Saha et al, 1976).…”

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confidence: 95%

Study of enzyme polymorphism and haemoglobin patterns amongst sixteen tribal populations of central India (Orissa, Madhya Pradesh, and Maharashtra)

et al. 1993

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SummaryA survey was conducted to study the genetic differentiation among 16 tribal groups of Orissa, Madhya Pradesh, and Maharashtra belonging to different ethnic and linguistic affiliations. Sixteen hundred and fifteen blood samples from both sexes were tested for 5 red cell enzyme systems: ACP, ESD, PGD, GLO, LDH, and Hb pattern. Three hundred and nineteen male individuals were tested for G-6-PD enzyme deficiency. The distribution of the enzyme markers and Hb show a range of variation which are more or less within the Indian range. Cases of homozygous HbSS were detected in all the tribes except 3 tribes in Orissa. Two cases of LDH Cal-I homozygote were found in two Dravidian language speaking Orissa tribes. The Z2-values for testing the homogeneity of gene frequencies indicate a non-significant heterogeneity for all alleles in the individual system. Within population diversity seems to be larger than between population diversity. The degree of over all genetic differentiation as measured by Gs~ value is 0.0154+0.0071.

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Population Genetic Studies in Kerala and the Nilgiris (South West India)

Cited by 29 publications

References 4 publications

Population genetic study of red cell enzyme phosphoglucose isomerase in India

Population genetic study of red cell enzyme phosphoglucose isomerase in India

Allelic variation in the NPY gene in 14 Indian populations

Study of enzyme polymorphism and haemoglobin patterns amongst sixteen tribal populations of central India (Orissa, Madhya Pradesh, and Maharashtra)

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