Population genetic study in two Transylvanian populations using forensically informative autosomal and Y-chromosomal STR markers

Egyed, Balázs; Füredi, S.; Pádár, Zsolt

doi:10.1016/j.forsciint.2005.10.020

Cited by 20 publications

(18 citation statements)

References 25 publications

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“…The sample for the Y-chromosome analysis included 229 individuals from Austrian Tyrol (North Tyrol), 683 from Freiburg and Munich (southern Germany), 17 231 from Zürich and Bern (Switzerland), 18 138 from Transylvania, 19 102 from Romania, 118 from Budapest (Hungary), 82 from Kiev (Ukraine), and 85 from Moscow (Russia). 17 In addition, a pan-European reference dataset composed of 6154 individuals was used.…”

Section: Population Samplesmentioning

confidence: 99%

“…The low mutation rate estimated in the Hutterites may reflect their history of recurrent bottlenecks, because such processes can affect estimates of mutation rates in our deep-rooted pedigree-based approach, as it has already been shown for phylogeny-based approaches. 44,45 To compare our data with the data from publicly available databases, [17][18][19] the minimal haplotype of seven common microsatellite markers was used ( Table 3). The South Tyrolean, Austrian (North Tyrol), and German samples shared six or eight haplotypes with the Hutterites, whereas the other populations shared five (Transylvania, Hungary) or fewer (Swiss, Romania, Ukraine, Russia) haplotypes with the Hutterites.…”

Section: Studies Of Y-chromosome Dnamentioning

confidence: 99%

“…[17][18][19] The repeat sizes of seven microsatellite loci (out of nine genotyped in the South Tyrolean and Hutterite samples) were available for all populations (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393); only haplotypes with frequency of at least two occurrences were included in the analysis. The …”

Section: Studies Of Y-chromosome Dnamentioning

confidence: 99%

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Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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Although the North American Hutterites trace their origins to South Tyrol, no attempts have been made to examine the genetic migration history of the Hutterites before emigrating to the United States in the 1870s. To investigate this, we studied 9 microsatellite loci and 11 unique event polymorphism (UEP) markers on the Y-chromosome, the hypervariable region I (HVRI) of the mitochondrial DNA (mtDNA), as well as the complete mtDNA genome of Hutterite and South Tyrolean samples. Only 6 out of 14 Y-chromosome UEP+microsatellite haplotypes and 3 out of 11 mitochondrial haplotypes that were present in the Hutterites were also present in the South Tyrolean population. The phylogenetic relationships inferred from Y-chromosome and mtDNA databases show that the Hutterites have a unique genetic background related to a similar extent to central and eastern European populations. An admixture analysis indicates, however, a relatively high genetic contribution of central European populations to the Hutterite gene pool. These results are consistent with historical records on Hutterite migrations and demographic history. In addition, our data reveal similar numbers of Y and mitochondrial haplotypes in Hutterite male and female founders, respectively. The Hutterite male and female gene pools are similar with respect to genetic diversity and genetic distance measures and comparable with respect to their origins, suggesting a similar evolutionary history.

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Section: Population Samplesmentioning

confidence: 99%

Section: Studies Of Y-chromosome Dnamentioning

confidence: 99%

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Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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“…The modern Hungarian population does not differ genetically from any other European population [35, cpRNFL circumpapillary retinal nerve fiber layer, GCC macular ganglion cell complex, G/T ratio macular ganglion cell complex thickness to total retinal thickness ratio, OR macular outer retinal thickness, TR macular total retinal thickness § Analysis of covariance (ANCOVA) adjusted for age, refractive error, IOP, MD and disc area 36], thus there is no reason to suppose that healthy Hungarian eyes would essentially differ from other European Caucasian eyes. Since high myopic eyes were not included in the current study, influence of pathological myopia on the results was eliminated.…”

Section: Discussionmentioning

confidence: 99%

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

et al. 2013

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“…Although, the analysis of Ychromosomal markers can provide complementary information in addition to an autosomal genetic profile [168], the most common application of Y-STRs is in cases of sexual assault, when the female component can greatly overshadow the male component, making autosomal STR profiling frequently difficult, unclear or impossible. Examination of Y-chromosome markers is available in a wide range of commercial kits [12, 169,170] which perform adequately for identifying male lineages.…”

Section: Brief History Of Uniparental Lineage Markersmentioning

confidence: 99%

Forensic DNA Technological Advancements as an Emerging Perspective on Medico-Legal Autopsy: A Mini Review

Pádár¹,

Zenke²,

Kozma³

2018

Post Mortem Examination and Autopsy - Current Issues From Death to Laboratory Analysis

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The importance of biological traces and evidences related to a criminal matter has been recognized for a long time. The examination of the expression of genetic polymorphism has been an integral part of the multidisciplinary field of medico-legal autopsy for over a century. Since the initial application of blood group antigens for personalization of a putative perpetrator in a murder case, the discipline of forensic genetics has evolved as a standard of forensic sciences. The real breakthrough, the application of molecular tools and processes for the in-vitro replication of genetic substances, has increasingly allowed the exploitation of advances of molecular genetics for both forensic and criminal investigations. Although there are certainly many more applications and scientific fields in the medico-legal arena, the relatively fast progress of genetics, which has accelerated recently with state-of-art technologies, can provide ever more relevant information in relation to a corpse or the cause and manner that resulted in the corpse for autopsy. This topic concerns the currently accepted forensic DNA technology, and the last section reviews commonly used markers for nuclear and mitochondrial DNA analysis as well as ongoing research. This review also focuses on the increasingly important non-human sources of DNA, and shortly covers the main aspects of animal forensic DNA examination.

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Population genetic study in two Transylvanian populations using forensically informative autosomal and Y-chromosomal STR markers

Cited by 20 publications

References 25 publications

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

Forensic DNA Technological Advancements as an Emerging Perspective on Medico-Legal Autopsy: A Mini Review

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