Population genetics of Glossina palpalis palpalis in sleeping sickness foci of Côte d’Ivoire before and after vector control

Berté, Djakaridja; Meeûs, Thierry De; Kaba, Dramane; Séré, Modou; Denis, Vincent; Courtin, Fabrice; Kassi, Martial N'Djetchi; Koffi, Mathurin; Jamonneau, Vincent; Ta, Bi Tra Dieudonné; Solano, Philippe; N’Goran, Eliézer K.; Ravel, Sophie

doi:10.1016/j.meegid.2019.103963

Cited by 16 publications

(18 citation statements)

References 70 publications

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“…Simulations were undertaken with EASYPOP (v. 2.0.1) (Balloux, 2001). We simulated random mating dioecious populations (pangamy), like what probably occurs in the wild for ticks (De Meeûs et al, 2021), Nematocera flies (Prudhomme, De Meeûs et al, 2020), Hemipteran bugs (Gomez-Palacio, Triana et al, 2013), or tsetse flies (Berté et al, 2019). We also simulated selfing monoecious populations, as flukes and water snails (Correa et al, 2017).…”

Section: Simulationsmentioning

confidence: 99%

“…We also checked how the cure of loci with stuttering signature, as proposed in a previous work (De Meeûs et al, 2021), restore the values expected for some parameters. We finally reanalyzed four real data sets on vectors and/or their parasite: the tick Ixodes scapularis in North America (De Meeûs et al, 2021); Glossina palpalis palpalis, vector of African trypnosomiasis in Côte d'Ivoire (Berté, De Meeus et al, 2019); the snail Galba truncatula and the fluke it transmits, Fasciola hepatica in France (Correa, De Meeûs et al, 2017); and Trypanosoma brucei gambiense, the agent of sleeping sickness in Guinea and Côte d'Ivoire (Koffi, De Meeûs et al, 2009). On these datasets, we checked if more loci with stuttering could be diagnosed, cured the loci with suspicion of stuttering, following the technique proposed recently (De Meeûs et al, 2021) to verify if some conclusions could be changed.…”

Section: Introductionmentioning

confidence: 99%

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A simple procedure to detect, test for the presence of stuttering, and cure stuttered data with spreadsheet programs

Meeûs¹,

Noûs²

2022

Peer Community Journal

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Microsatellites are powerful markers for empirical population genetics, but may be affected by amplification problems like stuttering that produces heterozygote deficits between alleles with one repeat difference. In this paper, we present a simple procedure that aims at detecting stuttering for each locus overall subsamples and only requires the use of a spreadsheet interactive application on any operating system. We compare the performances of this procedure with the one of MicroChecker on simulations of dioecious pangamic populations, monoecious selfing populations and clonal populations with or without stuttering, and on real data of vectors and parasites. We also propose a cure for loci affected and compare the results with those expected without stuttering. In sexual populations (dioecious or selfers), the new procedure appeared more than three times more efficient than MicroChecker. Cure was able to restore Wright's FIS of stuttered data to the expected value, and particularly so in selfing simulations. In clones, lack of segregation artificially increased false stuttering detection, and only highly significant stuttering tests and loci strongly deviating from others, could be usefully cured, in which case FIS estimate could be much improved. In doubt, and whenever possible, removal of affected and not curable loci may help to shift population genetics parameter estimates towards more reliable values.

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Section: Simulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A simple procedure to detect, test for the presence of stuttering, and cure stuttered data with spreadsheet programs

Meeûs¹,

Noûs²

2022

Peer Community Journal

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“…The travel history of the patient contributed to delay diagnosis as well. She spent her early childhood in Sinfra, a well-known HAT focus [ 3 , 36 , 37 , 38 , 39 ], where she was probably infected. Although Yabayo and Gagnoa are historic HAT foci, infection there seems less probable due to her short stay in Yabayo and an exclusively urban life as schoolgirl in Gagnoa, with little probability of exposure to tsetse flies.…”

Section: Discussionmentioning

confidence: 99%

The complex health seeking pathway of a human African trypanosomiasis patient in Côte d’Ivoire underlines the need of setting up passive surveillance systems

Kone

N’Gouan²,

Kaba³

et al. 2020

PLoS Negl Trop Dis

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Background Significant efforts to control human African trypanosomiasis (HAT) over the two past decades have resulted in drastic decrease of its prevalence in Cô te d'Ivoire. In this context, passive surveillance, integrated in the national health system and based on clinical suspicion, was reinforced. We describe here the health-seeking pathway of a girl who was the first HAT patient diagnosed through this strategy in August 2017. Methods After definitive diagnosis of this patient, epidemiological investigations were carried out into the clinical evolution and the health and therapeutic itinerary of the patient before diagnosis. Results At the time of diagnosis, the patient was positive in both serological and molecular tests and trypanosomes were detected in blood and cerebrospinal fluid. She suffered from important neurological disorders. The first disease symptoms had appeared three years earlier, and the patient had visited several public and private peripheral health care centres and PLOS NEGLECTED TROPICAL DISEASES

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“…This can be addressed through passive screening [ 7 ] and through vector control with Tiny Targets, a novel, cost-effective technology comprising insecticide-treated panels of material which attract and kill riverine tsetse [ 8 – 11 ]. Tiny Targets have been shown to reduce tsetse fly densities by more than 80% in Chad [ 12 , 13 ], Côte d’Ivoire [ 14 ], the Democratic Republic of the Congo (DRC) [ 15 ] and Uganda [ 9 ], but by a lower amount in Guinea, where the deployment methodology is different [ 16 ]. In Guinea and Chad, the use of Tiny Targets to reduce transmission has been shown to reduce the incidence of gHAT cases [ 12 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus

Bessell¹,

Esterhuizen

Lehane

et al. 2021

Parasites Vectors

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Background Riverine species of tsetse (Glossina) transmit Trypanosoma brucei gambiense, which causes Gambian human African trypanosomiasis (gHAT), a neglected tropical disease. Uganda aims to eliminate gHAT as a public health problem through detection and treatment of human cases and vector control. The latter is being achieved through the deployment of ‘Tiny Targets’, insecticide-impregnated panels of material which attract and kill tsetse. We analysed the spatial and temporal distribution of cases of gHAT in Uganda during the period 2010–2019 to assess whether Tiny Targets have had an impact on disease incidence. Methods To quantify the deployment of Tiny Targets, we mapped the rivers and their associated watersheds in the intervention area. We then categorised each of these on a scale of 0–3 according to whether Tiny Targets were absent (0), present only in neighbouring watersheds (1), present in the watersheds but not all neighbours (2), or present in the watershed and all neighbours (3). We overlaid all cases that were diagnosed between 2000 and 2020 and assessed whether the probability of finding cases in a watershed changed following the deployment of targets. We also estimated the number of cases averted through tsetse control. Results We found that following the deployment of Tiny Targets in a watershed, there were fewer cases of HAT, with a sampled error probability of 0.007. We estimate that during the intervention period 2012–2019 we should have expected 48 cases (95% confidence intervals = 40–57) compared to the 36 cases observed. The results are robust to a range of sensitivity analyses. Conclusions Tiny Targets have reduced the incidence of gHAT by 25% in north-western Uganda. Graphical abstract

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Population genetics of Glossina palpalis palpalis in sleeping sickness foci of Côte d’Ivoire before and after vector control

Cited by 16 publications

References 70 publications

A simple procedure to detect, test for the presence of stuttering, and cure stuttered data with spreadsheet programs

A simple procedure to detect, test for the presence of stuttering, and cure stuttered data with spreadsheet programs

The complex health seeking pathway of a human African trypanosomiasis patient in Côte d’Ivoire underlines the need of setting up passive surveillance systems

Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus

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