Population genetics of insertion–deletion polymorphisms in South Koreans using Investigator DIPplex kit

Seong, Ki Min; Park, Ji Hye; Hyun, Young Se; Kang, Pil Won; Choi, Dong Ho; Han, Myun Soo; Park, Ki Won; Chung, Ki Wha

doi:10.1016/j.fsigen.2013.06.013

Cited by 43 publications

(24 citation statements)

References 30 publications

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“…D A distances between the 16 groups with each other based on allelic frequencies of the 30 InDel loci were shown in Table 2. Short genetic distances were found between the Tujia group and Shanghai Han17, Guangdong Han18, South Korean23, Beijing Han9, Xibe10, She17, Tibetan9, and Yi16 groups; and further distances were observed between the Tujia group and Chinese Kazak9, Uigur9 groups; whereas the larger distances were estimated with Uruguayan24, Dane25, Central Spanish26, Basque26, and Hungarian populations27. Pairwise populations had small genetic distances, which indicated that they had close genetic relationships or shared a recent common ancestor.…”

Section: Resultsmentioning

confidence: 98%

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Shen

Zhu

Yao

et al. 2016

Sci Rep

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In the present study, thirty autosomal insertion and deletion polymorphic loci were simultaneously amplified and genotyped in a multiplex system, and their allelic frequencies as well as several forensic parameters were obtained in a sample of 236 unrelated healthy Tujia individuals. All the loci were in Hardy-Weinberg equilibrium after applying a Bonferroni correction and all pair-wise loci showed no significant linkage disequilibrium. These loci were observed to be relatively informative and discriminating, quite efficient for forensic applications. Allelic frequencies of 30 loci were compared between the Tujia group and other reference populations, and the results of analysis of molecular variance indicated the Tujia group showed the least significant differences with the Shanghai Han at one locus, and the most with Central Spanish population at 22 loci. We analyzed the population genetic structure by the principal component analysis, the clustering of STRUCTURE program and a Neighbor-Joining tree, and then evaluated the genetic relationships among Tujia and other 15 populations.

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Section: Resultsmentioning

confidence: 98%

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Shen

Zhu

Yao

et al. 2016

Sci Rep

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“…However, this panel should be used in combination with other markers to achieve enough power in paternity cases. Since this panel was originally designed for individual identification and all loci were highly polymorphic in the majority of populations worldwide [18,24,26,30,41], its efficacy for ancestry inference might be limited as previously proved [20].…”

Section: Discussionmentioning

confidence: 99%

Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci

et al. 2020

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According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of Hui people were native Chinese populations. In this context, the formation of Hui is due to simple cultural diffusion rather than demic diffusion. In this study, we examined the forensic and population genetic application of the 30 InDel loci in Hui population from Ningxia Hui Autonomous Region, Northwest China. Genotype analysis of 129 unrelated individuals revealed that all loci were in the Hardy–Weinberg equilibrium in Ningxia Hui. Forensic indices calculated from genotypes demonstrated that this panel, Qiagen DIPplex ® Investigator kit, was powerful enough to be used in individual identification but not in paternity cases. Through population genetic analysis, we found that Ningxia Hui received much more genetic contributions from East Asian populations than those from western Eurasian populations. Finally, we statistically identified the admixture signal of eastern and western Eurasians, although the latter is weak, in Ningxia Hui via the three-population test. All this evidence suggested that the formation of Ningxia Hui was mainly attributed to the cultural transformation of local Chinese residents with minor gene flow from western Eurasian populations.

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“…This kit allows the study of 30 InDel markers and the homologous gene of amelogenin as informative of the individual's sexual gender [12,16,17]. This multiplex has the advantage that amplified products can be separated and analyzed by capillary electrophoresis using an automatic sequencer, with similar technology to STR analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The Investigator® DIPplex kit (Qiagen, Hilden, Germany) has already been employed in some population studies, specially in populations of European, American and Asian origin [8][9][10]12,[16][17][18][19][20][21][22][23][24]. Demonstrating high discrimination power and high power of exclusion, has shown to be proper for forensic cases, specially, in individual identification that require analysis of degraded samples.…”

Section: Introductionmentioning

confidence: 99%

Study of InDel genetic markers with forensic and ancestry informative interest in PALOP’s immigrant populations in Lisboa

et al. 2016

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Population genetics of insertion–deletion polymorphisms in South Koreans using Investigator DIPplex kit

Cited by 43 publications

References 30 publications

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci

Study of InDel genetic markers with forensic and ancestry informative interest in PALOP’s immigrant populations in Lisboa

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