Population genomics of East Asian ethnic groups

Pan, Ziqing; Xu, Shuhua

doi:10.1186/s41065-020-00162-w

Cited by 30 publications

(11 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, East Asians are commonly known to endorse collectivist culture, and White Americans, to support individualist culture (Ran et al, 2021). The largest population in East Asians is Chinese, followed by Japanese and Korean (Pan & Xu, 2020). Pang et al (2017) found that Chinese Singaporeans suffering from mental illnesses experienced a higher level of social distance and physical threat connected to the influence of collectivism.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Global prevalence of stigmatization and violence against healthcare workers during the COVID‐19 pandemic: a systematic review and meta‐analysis

Saragih

Tarihoran

Rasool

et al. 2022

J of Nursing Scholarship

View full text Add to dashboard Cite

Purpose During COVID‐19, stigmatization and violence against and between professional healthcare workers worldwide are increasing. Understanding the prevalence of such stigmatization and violence is needed for gaining a complete picture of this issue. Therefore, the purpose of this review was to update estimates of the prevalence of stigmatization and violence against healthcare workers during the pandemic. Design A systematic review and meta‐analysis was conducted. Methods This review followed PRISMA guidelines and encompassed these databases: PubMed, Academic Search Complete, CINAHL, Web of Science, MEDLINE Complete, OVID (UpToDate), and Embase (from databases inception to September 15, 2021). We included observational studies and evaluated the quality of the study using the Joanna Briggs Institute methodology. Further, a random effects model was used to synthesis the pooled prevalence of stigmatization and violence in this study. Findings We identified 14 studies involving 3452 doctors, 5738 nurses, and 2744 allied health workers that reported stigmatization and violence during the pandemic. The pooled prevalence was, for stigmatization, 43% (95% confidence interval [CI]: 21% to 65%) and, for violence, 42% (95% CI: 30% to 54%). Conclusions Stigmatization and violence during the COVID‐19 pandemic were found to have affected almost half the studied healthcare workers. Healthcare professionals are more prone to be stigmatized by the community and to face workplace violence. Clinical Relevance Health administrators and policymakers should anticipate and promptly address stigmatization and violence against and between healthcare workers, while controlling the spread of COVID‐19. Health care systems should give serious attention to the mental health of all health providers.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The largest population in East Asians is Chinese, followed by Japanese and Korean (Pan & Xu, 2020). Pang et al (2017) found that Chinese Singaporeans suffering from mental illnesses experienced a higher level of social distance and physical threat connected to the influence of collectivism.…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

Global prevalence of stigmatization and violence against healthcare workers during the COVID‐19 pandemic: a systematic review and meta‐analysis

Saragih

Tarihoran

Rasool

et al. 2022

J of Nursing Scholarship

View full text Add to dashboard Cite

show abstract

“…However, the genetic origin and history of most minorities living in Yunnan are still opaque. A comparison of the genetic backgrounds and evolutionary histories of Yunnan minorities is required to uncover the human genetic diversity [4].…”

Section: Introductionmentioning

confidence: 99%

Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Yunnan is located in Southwest China and consists of great cultural, linguistic, and genetic diversity. However, the genomic diversity of ethnic minorities in Yunnan is largely under-investigated. To gain insights into population history and local adaptation of Yunnan minorities, we analyzed 242 whole-exome sequencing data with high coverage (~ 100–150 ×) of Yunnan minorities representing Achang, Jingpo, Dai, and Deang, who were linguistically assumed to be derived from three ancient lineages (the tri-genealogy hypothesis), i.e., Di-Qiang, Bai-Yue, and Bai-Pu. Results Yunnan minorities show considerable genetic differences. Di-Qiang populations likely migrated from the Tibetan area about 6700 years ago. Genetic divergence between Bai-Yue and Di-Qiang was estimated to be 7000 years, and that between Bai-Yue and Bai-Pu was estimated to be 5500 years. Bai-Pu is relatively isolated, but gene flow from surrounding Di-Qiang and Bai-Yue populations was also found. Furthermore, we identified genetic variants that are differentiated within Yunnan minorities possibly due to the living circumstances and habits. Notably, we found that adaptive variants related to malaria and glucose metabolism suggest the adaptation to thalassemia and G6PD deficiency resulting from malaria resistance in the Dai population. Conclusions We provided genetic evidence of the tri-genealogy hypothesis as well as new insights into the genetic history and local adaptation of the Yunnan minorities.

show abstract

“…The genetic background between the Thai and Chinese populations is substantially different. The Thai population is highly diversified in reflecting its genetic admixture with its neighboring population [ 61 ], whereas the Chinese population is relatively homogeneous in reflecting its relative stable evolutionary path in the East Asia region although having extensive internal heterogeneity [ 62 , 63 ]. The same analytic conditions and extensive filtering of normal genetic polymorphism used in the two studies provided a quality control to ensure the reliability of the mutation data derived for the comparison between the two TNBC cohorts.…”

Section: Discussionmentioning

confidence: 99%

Core promoter in TNBC is highly mutated with rich ethnic signature

Huang¹,

Zhang²,

Zhao³

et al. 2022

Briefings in Functional Genomics

View full text Add to dashboard Cite

The core promoter plays an essential role in regulating transcription initiation by controlling the interaction between transcriptional factors and sequence motifs in the core promoter. Although mutation in core promoter sequences is expected to cause abnormal gene expression leading to pathogenic consequences, limited supporting evidence showed the involvement of core promoter mutation in diseases. Our previous study showed that the core promoter is highly polymorphic in worldwide human ethnic populations in reflecting human history and adaptation. Our recent characterization of the core promoter in triple-negative breast cancer (TNBC), a subtype of breast cancer, in a Chinese TNBC cohort revealed the wide presence of core promoter mutation in TNBC. In the current study, we analyzed the core promoter in a Thai TNBC cohort. We also observed rich core promoter mutation in the Thai TNBC patients. We compared the core promoter mutations between Chinese and Thai TNBC cohorts. We observed substantial differences of core promoter mutation in TNBC between the two cohorts, as reflected by the mutation spectrum, mutation-effected gene and functional category, and altered gene expression. Our study confirmed that the core promoter in TNBC is highly mutable, and is highly ethnic-specific.

show abstract

Population genomics of East Asian ethnic groups

Cited by 30 publications

References 59 publications

Global prevalence of stigmatization and violence against healthcare workers during the COVID‐19 pandemic: a systematic review and meta‐analysis

Global prevalence of stigmatization and violence against healthcare workers during the COVID‐19 pandemic: a systematic review and meta‐analysis

Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan

Core promoter in TNBC is highly mutated with rich ethnic signature

Contact Info

Product

Resources

About