Population immunity to measles in Canada using Canadian Health Measures survey data – A Canadian Immunization Research Network (CIRN) study

Osman, Selma; Crowcroft, Natasha S.; McLachlan, Elizabeth; Hatchette, Todd; Perez-Iratxeta, Carol; Joh, Eugene; Wright, James E.; Halperin, Scott A.; Deeks, Shelley L.; Wilson, Sarah E.; Buchan, Sarah A; Ward, Brian J.; Gubbay, Jonathan B.; Brisson, Marc; Serhir, Bouchra; Severini, Alberto; Bolotin, Shelly

doi:10.1016/j.vaccine.2022.04.011

Cited by 4 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their measles antibody titer levels were derived entirely from vaccinations and waned as they aged because they lacked natural boosters, in contrast to adults in the past who were exposed to natural infections. This is comparable to the study in Canada, which found that measles seropositivity was 78.7% in adolescents [19]. Our study found that measles seropositivity rates in the Thai population aged 3-18 years were 82.7%, conflicting with the 2018 survey in Singapore that found that those aged 7-17 years had a 96.8% measles seropositivity rate.…”

Section: Discussioncontrasting

confidence: 60%

Low Measles Seropositivity Rate among Thai Adolescents in the Thai National Immunization Program

et al. 2022

View full text Add to dashboard Cite

To achieve the goal of measles elimination, herd immunity with 95% seroprotection in the community is required. This study aimed to describe the measles seropositivity rate among Thai children and adolescents. A cross-sectional study was conducted among children aged 3–18 years in Bangkok and its suburbs. Measles IgG antibodies were measured using a EUROIMMUN enzyme-linked immunosorbent assay kit. Seropositivity is defined as a measles IgG titer of ≥200 IU/L, due to a correlation with a >85% positive rate with a plaque reduction neutralizing titer of >120. Factors associated with seropositivity were analyzed using logistic regression analysis. From May to July 2020, 570 children with a median (IQR) age of 11.7 (9.4–14.8) years were enrolled. The geometric mean titer (GMT) of anti-measles IgG was 281 IU/L (95% CI; 257–306). The proportion of children with seropositivity was inversely correlated with age; 3–5 years 85.3%, 6–9 years 72.5%, 10–14 years 50.7%, and 15–18 years 56.3%. Adolescents aged 10–18 years had a lower measles seropositivity rate compared with young children; aOR 0.29 (95% CI 0.17–0.48). Only half of the adolescents who received two doses of measles-containing vaccine maintained measles IgG above the seropositive level. A measles booster dose for young adults may be needed to achieve the measles elimination goal.

show abstract

Section: Discussioncontrasting

confidence: 60%