The influence of the mechanisms of nuclear reactions on the population of isomeric states 44m Sc (6 +), 196m Au (12 −), 198m Au (12 −), 195m Hg (13/2 +), 197m Hg (13/2 +), 198m Tl (7 +), 196m Tl (7 +) obtained in reactions induced by beams of weakly bound and radioactive nuclei 3 He, 6 Li, 6 He are studied. In direct reactions involving cluster transfer, the isomeric ratio is lower than in reactions, where fusion with evaporation of nucleons occurs. In the case of charge exchange reactions with beams of weakly bound nuclei, the isomeric ratios change only slightly. If the reaction Q-value is positive, neutron transfer is observed with high probability in interactions of all weakly bound nuclei with both light and heavy stable target nuclei. Cross sections and their isomeric ratios differ for nucleon stripping and pickup channels owing to the difference in population of excited single-particle and collective states.