Population pharmacokinetic of antiepileptic drugs in different populations

Abstract

<jats:title>Abstract</jats:title><jats:p>This article reviews a population pharmacokinetics studies conducted during the past few years in Serbia. Studies have included three the most frequently used antiepileptic drugs (valproate, carbamazepine and lamotrigine) and different populations of epileptic patients: children, adults and heterogeneous population composed of both children and adults. The review compares obtained values of population pharmacokinetic models of clearance of these drugs, and factors that are significantly determined, making brief comments on the results of other authors on the same topic. Individualization of drug dosage is the basis of rational therapy, and factors of variability will always be subject of scientific research.</jats:p>

Population Pharmacokinetics of Valproate in Children: The Importance of Total Daily Dose, Compliance and Co-Treatment

“…In the present study, concomitant therapy with CBZ was detected as another determinant of VPA pharmacokinetics, but the association became evident only after non-compliant patients were excluded from the analysis. Having in mind that most of the earlier studies based their analyses on the data from apparently compliant patients 4,24,28 , our findings correspond well to the previosly published reports. It should be noted that the CBZ-related increase in VPA clearance, as both drugs are highly protein bound, could be at least partly also due to competition in protein binding 29 .…”

“…Based on the available literature, valproate (VPA) represents one of the most commonly used anticonvulsants worldwide 4 . It's narrow therapeutic range and high potential for drug-drug interactions at several pharmacokinetics levels often leads to pronounced intra-and inter-individual variability in VPA plasma concentration and response 5 .…”

Antibody conjugation to carboxyl-modified microspheres through N-hydroxysuccinimide chemistry for automated immunoassay applications: A general procedure

“…This pharmaceutical compound is widely employed to treat clinical seizure emergencies and as replacement therapy in epileptic patients [22], its persistence in wastewater turning it into an important anthropogenic marker and emerging pollutant [23]. Moreover, high interindividual variation is reported for CBZ metabolism, especially in co-therapy with other bioactive compounds, and thus the measurement of serum levels represents a step towards personalized medicine [24]. The feasibility of this approach was addressed at the proof-of-concept stage by assessing the binding of carbamazepine labeled with horseradish peroxidase to the decorated beads, inside the flow-based lab-on-valve (LOV) platform.…”