2021
DOI: 10.1007/s00228-021-03246-2
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Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder

Abstract: Purpose To develop and validate a population pharmacokinetic (PPK) model of valproic acid (VPA) in adult Chinese patients with bipolar disorder, and provide guidance for individualized therapy in this population. Methods A total of 1104 serum concentrations from 272 patients were collected in this study. The data analysis was performed using a nonlinear mixed-effects modeling approach. Covariates included demographic parameters, biological characteristics, and concomitant medications. Bootstrap validation (100… Show more

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Cited by 12 publications
(2 citation statements)
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“…The normalized transformation BW/62 could be put into simple practice. The influence of sex on CL by linear function shows that VPA metabolism is 17.41% faster in males compared with females, which is consistent with previous reports [ 32 ]. The typical value of CL is similar to that of patients who did not undergo neurosurgery [ 4 ].…”
Section: Discussionsupporting
confidence: 92%
“…The normalized transformation BW/62 could be put into simple practice. The influence of sex on CL by linear function shows that VPA metabolism is 17.41% faster in males compared with females, which is consistent with previous reports [ 32 ]. The typical value of CL is similar to that of patients who did not undergo neurosurgery [ 4 ].…”
Section: Discussionsupporting
confidence: 92%
“…As a narrow therapeutic index drug, it is characterized by high pharmacokinetic variability ( Johannessen and Johannessen, 2003 ). Various popPK models of VPA in Chinese patients have been constructed in recent years, to explore personalized VPA dosing and its variability patterns ( Xu et al, 2018 ; Zang et al, 2022a ). However, the covariates that influence the VPA pharmacokinetics varied between these models.…”
Section: Introductionmentioning
confidence: 99%