Population Registry of Esophageal and Stomach Tumours in Ontario (PRESTO): protocol for a multicentre clinical and pathological database including 25 000 patients

Abstract

IntroductionOesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a need to monitor and improve care for this disease. Pathologic information is a cornerstone of cancer diagnosis, treatment and prognosis. Few population-based studies combine pathology information and clinical outcomes. The objective of this study is to develop a clinical and pathological database of oesophagogastric cancers to study practice patterns, resource utilisation and clinical outcomes.Methods and analysisThe Population Registry of Esophageal and Stomach Tumours in Ontario (PRESTO) will include all patients with oesophagogastric cancer diagnosed from 2002 onwards within the province of Ontario. We estimate that the sample over the first 14 years of the study will include 26 000 patients. Pathologic information from diagnostic procedures, endomucosal resection specimens and surgical resection specimens is being abstracted into a purpose-built database. Pathology information will be linked to administrative data, which capture baseline demographics, patient-reported symptoms, physician billings, hospital visits, hospital characteristics, geography and vital statistics. The registry will be updated prospectively.Ethics and disseminationEthics approval for this study was obtained from the Sunnybrook Health Sciences Centre Research Ethics Board. The PRESTO database will enable the study of oesophagogastric cancer in Ontario under six themes of inquiry: treatment, surgical outcomes, pathology, survival, health system and resource utilisation and cost. This information will be a valuable addition to the global efforts to understand ways to optimise care for these diseases.

Análise prospectiva científica e tecnológica sobre imunoterapias para cânceres relacionados a região de cabeça e pescoço

“…Os resultados do quantitativo de cada descritor podem ser observados na Tabela 2 abaixo. Pacientes com HNC são acometidos por altos picos de dor, com grande incidência de sintomas durante o tratamento, e especialmente para pacientes que receberam radiação ou quimiorradiação, evidenciando a necessidade de vistoria dos sintomas durante a jornada dos pacientes com câncer de cabeça e pescoço (Gupta, et al, 2020). Frente a essa problemática, há evidências do sucesso das imunoterapias contra o câncer que tem a capacidade de alterar o panorama do tratamento do câncer, introduzindo um quarto pilar da terapia para os pacientes, assim, desenvolvendo tratamentos que visem o bem-estar do paciente diante de um tratamento exaustivo (Hiraoka, et al, 2019;Granier, et al, 2016).…”

Administrative and clinical databases: General thoracic surgery perspective on approaches and pitfalls

“…Recent investigator-initiated efforts have attempted to address this for gastroesophageal cancers, among others. 34 Another major limitation is related to the complete capture of people in the population. Although health care is generally funded provincially, aspects of health care for Indigenous peoples are funded federally and thus there is loss of data capture in those aspects of care that are funded through the provincial health insurance number.…”