2015
DOI: 10.1371/journal.pone.0131777
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Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak

Abstract: IntroductionFrom 2007 through 2010, the Netherlands experienced a large Q-fever epidemic, with 4,107 notifications. The most serious complication of Q-fever is chronic Q-fever.MethodIn 2014, we contacted all 2,161 adult inhabitants of the first village in the Netherlands affected by the Q-fever epidemic and offered to test for antibodies against Coxiella burnetii using immunofluorescence assay (IFA) to screen for chronic infections and assess whether large-scale population screening elsewhere is warranted.Resu… Show more

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Cited by 22 publications
(38 citation statements)
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“…As a consequence of the epidemic, many patients with underlying cardiac valve (or vascular) defects or prostheses could have been exposed to C. burnetii and might develop life-threatening endocarditis or vascular infections (76)(77)(78). Also, a high number of pregnant women could have been exposed to C. burnetii and might develop obstetrical complications and spontaneous abortions (79).…”
Section: The Different Epidemiological Profilesmentioning
confidence: 99%
“…As a consequence of the epidemic, many patients with underlying cardiac valve (or vascular) defects or prostheses could have been exposed to C. burnetii and might develop life-threatening endocarditis or vascular infections (76)(77)(78). Also, a high number of pregnant women could have been exposed to C. burnetii and might develop obstetrical complications and spontaneous abortions (79).…”
Section: The Different Epidemiological Profilesmentioning
confidence: 99%
“…From 2007 to 2010, a large outbreak of Q fever infected many individuals in the Netherlands. Although the epidemic ended in 2010, new chronic Q fever patients are still diagnosed in 2016 [4,5]. How C. burnetii persists and eventually causes chronic infection in these patients is still largely unknown.…”
Section: Introductionmentioning
confidence: 99%
“…For this scenario, we used larger geographic areas (3-digit postal code areas) and C. burnetii seroprevalences for each incidence area from the literature (24,25). In the second step, we estimated the risk for CQF using targeted screening studies for CQF conducted during or immediately after the epidemic (Appendix Table 4) (9)(10)(11)26,27). In the third step, we based the adjustment of the CQF prevalence from directly after the epidemic to the year of screening for the low CQF prevalence scenario on the reduction of CQF patients in the national CQF database over time (28).…”
Section: Cqf Prevalencementioning
confidence: 99%
“…We assumed a participation rate in the screening program of 50%, which is the lower bound of previous targeted screening programs for CQF in the Netherlands (10,27,30). The prevalence of CQF was assumed to be equal between participating and nonparticipating persons; hence, the participation rate affects only the number of CQF patients detected but not the cost-effectiveness of screening.…”
Section: Detection Rate Of Screening and Regular Carementioning
confidence: 99%