Population-specific brain [18F]-FDG PET templates of Chinese subjects for statistical parametric mapping

Abstract

Statistical Parametric Mapping (SPM) is a computational approach for analysing functional brain images like Positron Emission Tomography (PET). When performing SPM analysis for different patient populations, brain PET template images representing population-specific brain morphometry and metabolism features are helpful. However, most currently available brain PET templates were constructed using the Caucasian data. To enrich the family of publicly available brain PET templates, we created Chinese-specific template images based on 116 [18F]-fluorodeoxyglucose ([18F]-FDG) PET images of normal participants. These images were warped into a common averaged space, in which the mean and standard deviation templates were both computed. We also developed the SPM analysis programmes to facilitate easy use of the templates. Our templates were validated through the SPM analysis of Alzheimer’s and Parkinson’s patient images. The resultant SPM t-maps accurately depicted the disease-related brain regions with abnormal [18F]-FDG uptake, proving the templates’ effectiveness in brain function impairment analysis.

Comparison of performance between an F18-FDG PET normal brain template and a commercial template using the MIMneuro software

“…reported that even with the use of individual MRI scans in the creation of the template, there is still a degree of distortion. Nevertheless, both studies demonstrated that the application of a local template provides better results when used in a non-Caucasian population 22 …”

“…Nevertheless, both studies demonstrated that the application of a local template provides better results when used in a non-Caucasian population. 22 In our retrospective study, we only used subjects' PET images. The analysis workflow was predesigned, with the ability to be easily modified by the user, which is convenient and less time-consuming in practice.…”

Voxel-based analysis of the metabolic asymmetrical and network patterns in hypermetabolism-associated crossed cerebellar diaschisis

“…Finally, 169 patients (75 females; median [IQR] age, 58 [50–67] years) were introduced in this study. In addition, 116 normal brain 18 F-FDG PET images of healthy controls (39 females; median [IQR] age, 50 [41–60] years) were extracted from the open source image datasets ( Wang et al, 2021 ).…”

Diagnostic Superiority of 18F-FDG PET Over MRI in Detecting Anti-LGI1 Autoimmune Encephalitis

“…F-FDG PET images underwent spatial normalization using a population-specific brain 18 F-FDG PET template specifically tailored for Chinese subjects. 14 The Montreal Neurological Institute space served as the basis for this normalization process, using the symmetric diffeomorphic mapping algorithm in combination with advanced normalization tools. 15 A trilinear interpolation technique was applied to produce images composed of voxels measuring 2 Â 2 Â 2 mm.…”