Population Structure of Mycobacterium Tuberculosis in Russian Regions Bordering Eu Countries

Vyazovaya, Anna; Solovieva, Natalia; Gerasimova, Alena; Akhmedova, Gulnora; Turkin, Eugeni; Сунчалина, Т. В.; Tarashkevich, R.; Bogatin, S.; Gavrilova, Natalia S.; Bychkova, A.; Anikieva, E.; Zhuravlev, Viacheslav; Narvskaya, Olga; Mokrousov, Igor

doi:10.15789/2220-7619-2018-4-6.59

Russian Journal of Infection and Immunity

2018

DOI: 10.15789/2220-7619-2018-4-6.59

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Population Structure of Mycobacterium Tuberculosis in Russian Regions Bordering Eu Countries

Anna Vyazovaya

Natalia Solovieva

Alena Gerasimova

et al.

Abstract: .

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“…In this sense, it is noteworthy that Beijing CAO strains were highly prevalent in the prison setting in Kyrgyzstan (7). In contrast, strains of the Central Asian sublineage on the whole were shown to be more prevalent but less MDR-associated than Beijing B0/W148 strains in northwestern Russia (8) and West Siberia (9). It is possible that Russian strains of the Central Asian sublineage do not belong to CAO but to other clones.…”

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Simple Assay for Detection of the Central Asia Outbreak Clade of the Mycobacterium tuberculosis Beijing Genotype

et al. 2019

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The Central Asia outbreak (CAO) clade is a branch of the Mycobacterium tuberculosis Beijing genotype that is associated with multidrug resistance, increased transmissibility, and epidemic spread in parts of the former Soviet Union. Furthermore, migration flows bring these strains far beyond their areas of origin. We aimed to find a specific molecular marker of the Beijing CAO clade and develop a simple and affordable method for its detection. Based on the bioinformatics analysis of the large M. tuberculosis whole-genome sequencing (WGS) data set (n = 1,398), we identified an IS6110 insertion in the Rv1359-Rv1360 intergenic region as a specific molecular marker of the CAO clade. We further designed and optimized a multiplex PCR method to detect this insertion. The method was validated in silico with the recently published WGS data set from Central Asia (n = 277) and experimentally with M. tuberculosis isolates from European and Asian parts of Russia, the former Soviet Union, and East Asia (n = 319). The developed molecular assay may be recommended for rapid screening of retrospective collections and for prospective surveillance when comprehensive but expensive WGS is not available or practical. The assay may be especially useful in high multidrug-resistant tuberculosis (MDR-TB) burden countries of the former Soviet Union and in countries with respective immigrant communities.

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Simple Assay for Detection of the Central Asia Outbreak Clade of the Mycobacterium tuberculosis Beijing Genotype

et al. 2019

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Increased transmissibility of Russian successful strain Beijing B0/W148 of Mycobacterium tuberculosis: Indirect clues from history and demographics

Vyazovaya

Proshina²,

Gerasimova

et al. 2020

Tuberculosis

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Population Structure of Mycobacterium Tuberculosis in Russian Regions Bordering Eu Countries

Abstract: .

Cited by 2 publications

References 0 publications

Simple Assay for Detection of the Central Asia Outbreak Clade of the Mycobacterium tuberculosis Beijing Genotype

Simple Assay for Detection of the Central Asia Outbreak Clade of the Mycobacterium tuberculosis Beijing Genotype

Increased transmissibility of Russian successful strain Beijing B0/W148 of Mycobacterium tuberculosis: Indirect clues from history and demographics

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