Porcine Deltacoronavirus, Thailand, 2015

Janetanakit, Taveesak; Lumyai, Mongkol; Bunpapong, Napawan; Boonyapisitsopa, Supanat; Chaiyawong, Supassama; Nonthabenjawan, Nutthawan; Kesdaengsakonwut, Sawang; Amonsin, Alongkorn

doi:10.3201/eid2204.151852

Cited by 128 publications

(113 citation statements)

References 10 publications

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“…In our present study, we found that the prevalences of PDCoV, PEDV and PDCoV + PEDV in Tibetan pigs were significantly lower than in pigs in other provinces of China (Dong et al., ; Song et al., ), South Korea (Jang, Lee, Kim, & Lee, ), Thailand (Janetanakit et al., ; Saeng‐Chuto et al., ) and the United States(Wang et al., ). The prevalence of PDCoV in Tibetan pigs was relatively low (3.70%), and only piglets were affected.…”

Section: Discussionmentioning

confidence: 44%

Detection and genetic characterization of porcine deltacoronavirus in Tibetan pigs surrounding the Qinghai-Tibet Plateau of China

Wang

Baloch

et al. 2018

Transbound Emerg Dis

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Porcine deltacoronavirus (PDCoV) is a recently discovered RNA virus that belongs to the family Coronaviridae and genus Deltacoronavirus. This virus causes enteric disease in piglets that is characterized by enteritis and diarrhoea. In our present investigation, 189 diarrhoeic samples were collected between July 2016 and May 2017 from Tibetan pigs inhabiting in three different provinces surrounding the Qinghai-Tibet Plateau of China. We then applied the molecular-based method of reverse transcription polymerase chain reactions (RT-PCRs) to detect the presence of PDCoV in collected samples, and RT-PCR indicated that the prevalence of PDCoV was 3.70% (7/189) in Tibetan pigs. Four of 7 PDCoV-positive pigs were monoinfections of PDCoV, three samples were co-infections of PDCoV with porcine epidemic diarrhoea virus (PEDV), and 52 (27.51%) samples were positive for PEDV. Four strains with different full-length genomes were identified (CHN/GS/2016/1, CHN/GS/2016/2, CHN/GS-/2017/1 and CHN/QH/2017/1), and their genomes were used to analyse the characteristics of PDCoV currently prevalent in Tibetan pigs. We found a 3-nt insertion in the spike gene in four strains in Tibetan pigs. Phylogenetic analysis of the complete genome and spike and nucleocapsid gene sequences revealed that these strains shared ancestors with the strain CHN-AH-2004, which was found in pigs from the Anhui province of China mainland. However, PDCoV strains from Tibetan pigs formed different branches within the same cluster, implying continuous evolution in the field. Our present findings highlight the importance of epidemiologic surveillance to limit the spread of PDCoV in livestock at high altitudes in China.

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Section: Discussionmentioning

confidence: 44%

Detection and genetic characterization of porcine deltacoronavirus in Tibetan pigs surrounding the Qinghai-Tibet Plateau of China

Wang

Baloch

et al. 2018

Transbound Emerg Dis

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“…Strain 03 is more related on a genomic scale to the Thai strains and had the lowest nucleotide identity with CHN/GD02/2015 and CHN/GX01/2015 (95.8%, Table S2) (Zhai et al., ), which were collected from Guangdong and nearby Guangxi provinces. However, the N gene of this strain revealed a completely reverse conclusion; that it belongs to the Chinese group with a low nt identity (96.7%) with the Thai strains S5011 and 5015L (Janetanakit et al., ) (Fig. and Table S3).…”

Section: Discussionmentioning

confidence: 89%

“…It was identified later in several states of USA (Li et al., ; Marthaler, Jiang, Collins, & Rossow, ; Wang, Byrum, & Zhang, ) and has now spread to South Korea, mainland China, Thailand and Laos (Lee & Lee, ; Lee et al., ; Lorsirigool et al., ; Madapong et al., ; Song et al., ). The emergence of PDCoV was most often associated with clinical infection symptoms including diarrhoea, vomiting and dehydration in pigs, especially in sucking and nursing piglets (Janetanakit et al., ; Ma et al., ; Marthaler, Raymond et al ; Song et al., ). These worldwide outbreaks of PDCoV have caused economic losses to the global commercial swine industry (Chen, Gauger et al., ; Chen, Zhu et al., ; Homwong et al., ; Song et al., ; Wang et al., ).…”

Section: Introductionmentioning

confidence: 99%

The detection and phylogenetic analysis of porcine deltacoronavirus from Guangdong Province in Southern China

Mai

Feng

Chen

et al. 2017

Transbound Emerg Dis

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Porcine deltacoronavirus (PDCoV) is a newly discovered coronavirus that causes diarrhoea, vomiting and dehydration in sucking and nursing piglets. It was first reported in Hong Kong in 2012 and has since been discovered in the United States, Canada, South Korea, mainland China, Thailand and Laos. PDCoV has been experimentally proved to lead to diarrhoea in swine and it was detected positive in pigs in Guangdong, southern China. In our study, 252 faecal and intestinal samples from sucking piglets and sows with diarrhoea were surveyed for common enteric viruses. We found a prevalence of PDCoV (21.8%), porcine epidemic diarrhoea virus (65.5%), transmissible gastroenteritis virus (0%), rotavirus group A (25.0%) and porcine kobuvirus (68.7%). We isolated 13 PDCoV strains and discovered that PDCoV infections were often co-infections with kobuvirus rather than the commonly linked porcine epidemic diarrhoea virus. Phylogenetic analysis of S gene and N gene revealed that 11 of 13 PDCoV strains belonged to Chinese lineage. As for the left two strains, one single strain (CHN-GD16-05) belonged to American and Korean lineages while another strain (CHN-GD16-03) was similar to a Thai strain, but only in the S gene. This suggested a possible recombination event between the Thai and the newly described Chinese strain.

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“…The clinical symptoms of PDCoV disease are very similar to those of porcine epidemic diarrhea, but PDCoV disease is milder [4]. Since April 2017, disease caused by PDCoV strains has been reported in North America (the United States, Canada, and Mexico) [5][6][7][8][9][10] and Asia, including South Korea, Mainland China, Thailand, Laos, and Vietnam [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Genome Sequencing and Analysis of a Porcine Delta Coronavirus from Eastern China

Yang¹,

Ju²,

Wang³

et al. 2017

Eur J Exp Bio

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Porcine Deltacoronavirus, Thailand, 2015

Cited by 128 publications

References 10 publications

Detection and genetic characterization of porcine deltacoronavirus in Tibetan pigs surrounding the Qinghai-Tibet Plateau of China

Detection and genetic characterization of porcine deltacoronavirus in Tibetan pigs surrounding the Qinghai-Tibet Plateau of China

The detection and phylogenetic analysis of porcine deltacoronavirus from Guangdong Province in Southern China

Genome Sequencing and Analysis of a Porcine Delta Coronavirus from Eastern China

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