Porcine dermis implants in soft-tissue reconstruction: current status

Abstract

Soft-tissue reconstruction for a variety of surgical conditions, such as abdominal wall hernia or pelvic organ prolapse, remains a challenge. There are numerous meshes available that may be simply categorized as either synthetic or biologic. Within biologic meshes, porcine dermal meshes have come to dominate the market. This review examines the current evidence for their use and the limitations of knowledge. Although there is increasing evidence to support their safety, long-term follow-up studies that support their efficacy are lacking. Numerous clinical trials that remain ongoing may help elucidate their precise role in soft-tissue reconstruction.

Tissue Reactions to Heterogenic and Allogeneic Acellular Dermal Matrix Mesh Placed in the Vesicovaginal Space in a Rabbit Model

“…These results suggest that allogeneic mesh is more suitable for clinical use than heterogenic mesh. ADM mesh has become popular in the past decade, and has been used for the treatment of burns, in plastic and general surgery and stomatology, for vaginal and pelvic floor reconstruction, repair of genital tract fistula, and abdominal wall repair after fascial defects [18] . When used for pelvic floor reconstruction, ADM mesh has been shown to be associated with a lower rate of mesh-related complications as compared to synthetic meshes [19] .…”

Are agricultural and natural sources of bio-products important for modern regenerative medicine? A review

“…EFLL extract enhances the osteogenic differentiation of mesynchymal stem cells (MSCs) particular, it is seen as viable in fully personalized treatments where there is a rapid need to perform life-saving surgical procedures [32]. Some specific examples of porcine decellularized dermal graft utilization in clinical and experimental practice are presented in Table 4.…”

The development of SERI® Surgical Scaffold, an engineered biological scaffold

“…ADMs have been used in a variety of procedures (e.g., burn injury resurfacing, breast implant support, abdominal hernia repair) and show promise for other aesthetic and reconstructive purposes . However, their utility may be limited by size, strength, cost, and concerns regarding adverse events . Additional options for soft tissue reinforcement include absorbable or permanent synthetic mesh.…”

“…4 However, their utility may be limited by size, strength, cost, and concerns regarding adverse events. 5 Additional options for soft tissue reinforcement include absorbable or permanent synthetic mesh. Overall, these products are commonly used to provide additional support during breast reconstruction [6][7][8] and during 25 Silk Yes a Acellular dermal matrix NA Human AlloDerm R (LifeCell Corp., Branchburg, NJ) 43 Human dermis AlloMax TM (Davol, Inc., Warwick, RI) 44 Human dermis DermaMatrix TM (Synthes, West Chester, PA) 45 Human dermis FlexHD R (Musculoskeletal Transplant Foundation, Edison, NJ) 46 Human dermis Repriza R (Specialty Surgical Products, Inc., Victor, MT) 47…”