Porcine <i>LIF</i> gene polymorphisms and their association with litter size traits in four pig breeds

Ding, Yueyun; Ding, Chong; Wang, Xudong; Wu, Chaodong; Li, Qian; Li, Dengtao; Zhang, Wei; Wang, Yuanlang; Yang, Min; Wang, Li; Ding, Jian; Zhang, Xiaodong; Gao, Yafei; Yin, Zhan

doi:10.1139/cjas-2018-0228

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…The porcine LIF c.*24C was the major allele in these pig populations. These results are agreed with previous studies, which showed that the porcine LIF c.*24C was a major allele in several pig breeds such as German Landrace (Spötter et al, 2009), Large White (Leonova et al, 2015), and four Chinese pig breeds (Ding et al, 2020). However, the porcine LIF c.*24T was the major allele in German synthetic line (Spötter et al, 2005), German Large White (Spötter et al, 2009), Polish Large White and Polish Landrace (Mucha et al, 2013), and Landrace and Duroc (Leonova et al, 2015).…”

Section: Discussionsupporting

confidence: 92%

“…The porcine LIF c.*24C was a favorable allele to increase litter size. This result agreed with previous studies which found the porcine LIF c.*24C to be a favorable allele for litter size traits in several pig breeds (Spötter et al, 2005;Lin et al, 2009;Leonova et al, 2015;Ding et al, 2020). However, at porcine LIF c.*24C>T locus of the Polish Large White and Polish Landrace pigs with TT genotype had higher litters compared with CC and CT genotypes (Mucha et al, 2013).…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, the porcine LIF gene is located closely with the QTL regions for total number born alive (37.5-38.5 Mb), total number born (41.8-42.0 Mb), and total litter weight (56.4-56.6 Mb) (Onteru et al, 2012;Schneider et al, 2012). Additionally, significant associations of the porcine LIF polymorphism with litter traits have been reported in several pig breeds (Spötter et al, 2005;Lin et al, 2009;Spötter et al, 2009;Mucha et al, 2013;Leonova et al, 2015;Ding et al, 2020). All these shreds of evidence indicated that the LIF function was critical for embryonic implantation and embryonic survival.…”

Section: Introductionmentioning

confidence: 95%

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Effect of leukemia inhibitory factor polymorphism on litter size traits in Thai commercial pig breeds

Norseeda

Liu

Teltathum³

et al. 2020

VIS

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Leukemia inhibitory factor (LIF) is a crucial candidate gene that impacts on implantation process. In this study, the effects of the porcine LIF polymorphism on litter size traits were elucidated in Thai commercial pig populations. Genotyping of three single nucleotide polymorphisms (SNPs) of the porcine LIF gene was detected in coding and 3ˊ-untranslated regions. The porcine LIF c.*24C>T was segregating in Large White, Landrace, and Large White × Landrace (LW × LR) crossbred sows. No polymorphisms at two non-synonymous SNPs loci (LIF c.28C>A and LIF c.161A>G) were found in this study. The porcine LIF c.*24C>T was significantly associated with the total number born (TNB), the number born alive (NBA), and the number of piglets weaned alive (NWA) traits in Large White and Landrace sows. Moreover, the porcine LIF c.*24C>T was associated with the NBA and NWA traits in LW × LR crossbred sows. The favorable LIF c.*24C allele was positively correlated with the litter size traits. These findings indicated that the polymorphism of the porcine LIF gene was associated with litter size traits and confirms the significance of porcine LIF as a candidate gene for litter size traits in pig breeding. Thus, the porcine LIF gene could be used for improving prolific traits in these Thai commercial pig populations.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 95%

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Effect of leukemia inhibitory factor polymorphism on litter size traits in Thai commercial pig breeds

Norseeda

Liu

Teltathum³

et al. 2020

VIS

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“…Among these, since the NL pigs are characterized by a low number of newborns per delivery (according to our data, mean value of 6.6 ± 1.9) and their cured products are strongly appreciated, two genes, Leukemia Inhibitory Factor (LIF) and 2,4-Dienoyl-CoA Reductase 1 (DECR1), are, according to us, particularly worthy of consideration. In fact, the former shows polymorphisms associated with litter size variation in pig [ 33 , 34 ], and the latter polymorphisms associated with variation in lipid composition traits [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Nero Lucano Pig Breed: Recovery and Variability

Valluzzi

Rando

Macciotta

et al. 2021

Animals

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The Nero Lucano (NL) pig is a black coat colored breed characterized by a remarkable ability to adapt to the difficult territory and climatic conditions of Basilicata region in Southern Italy. In the second half of the twentieth century, technological innovation, agricultural evolution, new breeding methods and the demand for increasingly lean meat brought the breed almost to extinction. Only in 2001, thanks to local institutions such as: the Basilicata Region, the University of Basilicata, the Regional Breeders Association and the Medio Basento mountain community, the NL pig returned to populate the area with the consequent possibility to appreciate again its specific cured meat products. We analyzed the pedigrees recorded by the breeders and the Illumina Porcine SNP60 BeadChip genotypes in order to obtain the genetic structure of the NL pig. Results evidenced that this population is characterized by long mean generation intervals (up to 3.5 yr), low effective population size (down to 7.2) and high mean inbreeding coefficients (FMOL = 0.53, FROH = 0.39). This picture highlights the low level of genetic variability and the critical issues to be faced for the complete recovery of this population.

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“…Hundreds of pig breeds have evolved with different breeding goals and selection systems. Most of these breeds exhibit special characteristics such as high fertility (Meishan pigs), hypoxic adaptation (Tibetan pigs), advantageous growth, and high feed conversion rates (Large White pigs) [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Selection Signatures in Anqing Six-End-White Pigs Based on Resequencing Data

Chen

Wang

et al. 2022

Genes

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As a distinguished Chinese indigenous pig breed that exhibits disease resistance and high meat quality, the Anqing six-end-white (AQ) pig represents a valuable germplasm resource for improving the quality of the pig breeding industry. In this study, 24 AQ pigs that were distantly blood-related and 6 Asian Wild Boar (AWB) were selected for 10× deep-genome resequencing. The signatures of the selection were analyzed to explore the genetic basis of their germplasm characteristics and to identify excellent germplasm-related functional genes based on NGS data. A total of 49,289,052 SNPs and 6,186,123 indels were detected across the genome in 30 pigs. Most of the genetic variations were synonym mutations and existed in the intergenic region. We identified 275 selected regions (top 1%) harboring 85 genes by applying a crossover approach based on genetic differentiation (FST) and polymorphism levels (π ratio). Some genes were found to be positively selected in AQ pigs’ breeding. The SMPD4 and DDX18 genes were involved in the immune response to pseudorabies virus (PRV) and porcine reproductive and respiratory syndrome virus (PRRSV). The BCL6 and P2RX6 genes were involved in biological regulation of immune T cells and phagocytes. The SLC7A4 and SPACA4 genes were related to reproductive performance. The MSTN and HIF1A genes were related to fat deposition and muscle development. Moreover, 138 overlapping regions were detected in selected regions and ROH islands of AQ pigs. Additionally, we found that the QTLs with the most overlapping regions were related to back fat thickness, meat color, pH value, fatty acid content, immune cells, parasitic immunity, and bacterial immunity. Based on functional enrichment analysis and QTLs mapping, we conducted further research on the molecular genetic basis of germplasm traits (disease resistance and excellent meat quality). These results are a reliable resource for conserving germplasm resources and exploiting molecular markers of AQ pigs.

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Porcine LIF gene polymorphisms and their association with litter size traits in four pig breeds

Cited by 3 publications

References 31 publications

Effect of leukemia inhibitory factor polymorphism on litter size traits in Thai commercial pig breeds

Effect of leukemia inhibitory factor polymorphism on litter size traits in Thai commercial pig breeds

The Nero Lucano Pig Breed: Recovery and Variability

Detection of Selection Signatures in Anqing Six-End-White Pigs Based on Resequencing Data

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