Porcine major histocompatibility complex

Vaiman, M.; Chardon, Patrick; Rothschild, Max F.

doi:10.20506/rst.17.1.1093

Cited by 40 publications

(37 citation statements)

References 60 publications

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“…It is important to remember that many of the associations observed between the pig MHC region and its traits, were previously observed in the mouse H-2 region [23], and occasionally also in domestic species such as cattle and chickens. A number of these associations concerned traits related to reproductive functions, including embryo development, litter size, mating preference, and sometimes miscarriage [40]. The MHC class Ia molecules are probably not involved in any of these associations, since these molecules are not expressed at the surface of the embryos.…”

Section: Discussionmentioning

confidence: 99%

“…Among the genes located in the MHC region which are not related to the class I genes, the presence of olfactory factors encoding genes is worth noting in connection with the importance for gilt puberty or boar taint. Similarly, the tissue level of androstenone, a compound which functions like a pheromone in the boar, is also controlled by the SLA region, although the gene involved has not yet been characterised [40]. Among the other peculiarities of swine reproduction, the segregation of the SLA H07 haplotype was observed to deviate significantly from the usual 1 :1 ratio in a number of back-cross families.…”

Section: Discussionmentioning

confidence: 99%

“…The class III region spans about 700 kb of DNA and contains over 35 characterised genes [40]. Many of them are involved in important non-specific or innate defence mechanisms, such as the complement components, the TNF gene families, the Hsp70 gene family, the RAGE gene and the allograft inflammatory factor-1 (Tab.…”

Section: The Sla Class III Regionmentioning

confidence: 99%

“…Similarly a recently published review [40] was devoted to the responsability of the SLA complex for at least part of the genetic control of the immune response involving both antibodies and cellular responses to conventional antigens, pathogenic viruses and the nematode Trichinella spiralis.…”

Section: The Sla Complex and Immune Responsivenessmentioning

confidence: 99%

“…A wide variety of productive and reproductive traits is affected by SLA specific haplotypes [40]. An extensive evaluation of these traits was recently conducted in a large herd of F2 pigs issued from initial matings of Meishan and French Large White grandparents.…”

Section: The Swine Leukocyte Antigen and Production Performancesmentioning

confidence: 99%

See 4 more Smart Citations

The porcine Major Histocompatibility Complex and related paralogous regions: a review

Chardon¹,

Renard²,

Gaillard³

et al. 2000

Genet. Sel. Evol.

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-The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Sla Class III Regionmentioning

confidence: 99%

Section: The Sla Complex and Immune Responsivenessmentioning

confidence: 99%

Section: The Swine Leukocyte Antigen and Production Performancesmentioning

confidence: 99%

See 3 more Smart Citations

The porcine Major Histocompatibility Complex and related paralogous regions: a review

Chardon¹,

Renard²,

Gaillard³

et al. 2000

Genet. Sel. Evol.

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Regulation of porcine classical and nonclassical MHC class I expression

Tennant¹,

Renard²,

Chardon³

et al. 2007

Immunogenetics

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Major histocompatibility complex (MHC) class I molecules comprise a family of polymorphic cell surface receptors consisting of classical 1 a molecules that present antigenic peptides and nonclassical 1 b molecules. Gene expression for human classical and nonclassical MHC class I molecules has been shown to be differentially regulated by interferon, with variation in the nucleotide sequence of promoter regions, resulting in differences in interferon inducibility and basal levels of gene transcription. In this study on porcine classical and nonclassical swine leukocyte Ag (SLA) class I molecules, we show alignments of putative regulatory elements in the promoters of the three functional classical class I genes, SLA-1, SLA-2, and SLA-3; two nonclassical 1 b genes, SLA-6 and SLA-7; and a MIC-2 gene. Promoter elements were cloned upstream from a luciferase reporter gene, and the basal and inducible activities of each were characterized by expression in Max cells, an immortalized pig cell line that responds to interferon and tumor necrosis factor alpha (TNF-alpha). All three classical class I but not nonclassical promoters responded to interferon. This was confirmed by the transactivation of SLA-1, but not SLA-7, after the co expression with interferon regulatory factors (IRFs), IRF-1, IRF-2, IRF-3, IRF-7, and IRF-9. Classical class I genes were activated by cotransfection with nuclear factor kappa B (NF-kappaB) p65 and by treatment of cells with TNF-alpha, although, unlike human promoter there was no synergistic effect with interferon. The greatest effect on classical class I promoters was coexpression with the class II transactivator (CIITA), important for constitutive transactivation. These results determine the differential regulation of porcine classical and nonclassical MHC class I and reflects their importance in antigen presentation during infection.

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Microsatellite diversity and crossover regions within homozygous and heterozygous SLA haplotypes of different pig breeds

Andõ¹,

Uenishi²,

Kawata³

et al. 2008

Immunogenetics

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Our aim was to investigate microsatellite (MS) diversity and find crossover regions at 42 polymorphic MS loci in the swine leukocyte antigen (SLA) genomic region of 72 pigs with different well-defined homozygous and heterozygous SLA haplotypes. We analyzed the genetic polymorphisms of 42 MS markers in 23 SLA homozygous-heterozygous, common pig breeds with 12 SLA serological haplotypes and 49 National Institutes of Health (NIH) and Clawn homozygous-heterozygous miniature pigs with nine SLA serological or genotyped haplotypes including four recombinant haplotypes. In comparing the same and different haplotypes, both haplospecific patterns and allelic variations were observed at the MS loci. Some of the shared haplotype blocks extended over 2 Mb suggesting the existence of strong linkage disequilibrium (LD) in the entire SLA region. Crossover regions were easily defined by the MS markers within the class I and/or III region in the NIH and Clawn recombinant haplotypes. The present haplotype comparison shows that our set of MS markers provides a fast and cost-efficient alternative, or complementary, method to the serological or sequence-based determination of the SLA alleles for the characterization of SLA haplotypes and/or the crossover regions between different haplotypes.

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Porcine major histocompatibility complex

Cited by 40 publications

References 60 publications

The porcine Major Histocompatibility Complex and related paralogous regions: a review

The porcine Major Histocompatibility Complex and related paralogous regions: a review

Regulation of porcine classical and nonclassical MHC class I expression

Microsatellite diversity and crossover regions within homozygous and heterozygous SLA haplotypes of different pig breeds

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