Porcine Toll-like receptor 1, 6, and 10 genes: Complete sequencing of genomic region and expression analysis

Shinkai, Hiroki; Muneta, Yoshihiro; Suzuki, Kohei; Eguchi-Ogawa, Tomoko; Awata, Takashi; Uenishi, Hirohide

doi:10.1016/j.molimm.2005.09.006

Cited by 47 publications

(28 citation statements)

References 25 publications

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“…Most notably, TLR1 and TLR6 have identical RNFVPG BB loop sequences, whereas that of TLR10 is composed of SYFDPG and includes a two-amino acid insertion in the preceding a-helix. These and other differences within the TLR10 signaling domain may contribute to a distinct charge distribution in the TLR2/10 surface that confers a unique specificity for adapter binding and downstream signaling (54). We observed that the adaptor MyD88 coimmunoprecipitates with the TLR2/10 heterodimer and that this interaction is enhanced by lipopeptide agonist (Fig.…”

Section: Discussionmentioning

confidence: 76%

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

Guan

Rañoa

Jiang

et al. 2010

The Journal of Immunology

218

256

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Section: Discussionmentioning

confidence: 76%

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

Guan

Rañoa

Jiang

et al. 2010

The Journal of Immunology

218

256

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“…TLR1 is expressed in peripheral blood lymphocytes, epithelial cells, and endothelial cells (5,6). TLR10 is highly expressed in the spleen (7) and B cells (8) and expressed at lower levels in the lungs, the small intestine, the stomach, the thymus, peripheral blood lymphocytes, lymph nodes, and the tonsils (5,7,9). TLR1, TLR6, and TLR10 activate the nuclear factor-nB pathway (2).…”

Section: Introductionmentioning

confidence: 99%

Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

Chen

Giovannucci

Kraft

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Chronic inflammation may be a risk factor for prostate cancer. Previously, we found significant associations between single nucleotide polymorphisms (SNPs) and haplotypes in Toll-like receptor (TLR) 4 and the risk of prostate cancer. TLR6, TLR1, and TLR10 are also involved in the pathogen-mediated inflammation pathway. A Swedish study observed associations between sequence variants in the TLR6-TLR1-TLR10 gene cluster and the risk of prostate cancer. We assessed if genetic polymorphisms of this gene cluster were associated with the risk of prostate cancer in a U.S. population. Methods: In a nested case-control design within the Health Professionals Follow-Up Study, we identified 700 participants with prostate cancer who were diagnosed after they had provided a blood specimen in 1993 and by January 31, 2000. Controls were 700 age-matched men without prostate cancer who had had a prostate-

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“…The Toll receptor was initially identified in Drosophila melanogaster for its role in embryonic development and was recognized as a key regulator of immune response (Leulier and Lemaitre 2008). TLRs have been identified in many animal species, including pigs (Shinkai et al 2006), chickens (Fukui et al 2001), fish (Tsujita et al 2004), and insects (Tauszig et al 2000;Imamura and Yamakawa 2002;Aronstein and Saldivar 2005). It has been estimated that most mammalian species have between 10 and 15 types of Toll-like receptors (Roach et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Fine-Scale Analysis of Parasite Resistance Genes in the Red Flour Beetle, Tribolium castaneum

et al. 2013

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Parasite infection impacts population dynamics through effects on fitness and fecundity of the individual host. In addition to the known roles of environmental factors, host susceptibility to parasites has a genetic basis that has not been well characterized. We previously mapped quantitative trait loci (QTL) for susceptibility to rat tapeworm (Hymenolepis diminuta) infection in Tribolium castaneum using dominant AFLP markers; however, the resistance genes were not identified. Here, we refined the QTL locations and increased the marker density in the QTL regions using new microsatellite markers, sequence-tagged site markers, and single-strand conformational polymorphism markers. Resistance QTL in three linkage groups (LG3, LG6, and LG8) were each mapped to intervals ,1.0 cM between two codominant markers. The effects of 21 genes in the three QTL regions were investigated by using quantitative RT-PCR analysis, and transcription profiles were obtained from the resistant TIW1 and the susceptible cSM strains. Based on transcription data, eight genes were selected for RNA interference analysis to investigate their possible roles in H. diminuta resistance, including cytochrome P450 (LOC657454) and Toll-like receptor 13 (TLR13, LOC662131). The transcription of P450 and TLR13 genes in the resistant TIW1 strains was reduced more than ninefold relative to the control. Moreover, the effects of gene knockdown of P450 and TLR13 caused resistant beetles to become susceptible to tapeworm infection, which strongly suggests an important role for each in T. castaneum resistance to H. diminuta infection. P ARASITES exert negative effects on host survivorship and reproductive success, and in turn hosts develop resistance to parasites by reducing susceptibility to infection. Despite the importance to medicine and agriculture of host resistance to parasitism, and the fact that host resistance is genetically determined, the genetics of parasite resistance in insect hosts is not well known. Infection of the red flour beetle, Tribolium castaneum, by the rat tapeworm, Hymenolepis diminuta, has been well characterized with regard to hostparasite interactions (Keymer and Anderson 1979;Zhong et al. 2003Zhong et al. , 2005. The system also represents an excellent model to study the evolutionary genetics of resistance to parasite infection, as infection can be easily controlled and monitored in the laboratory. Serving as an intermediate host, infection of Tribolium by H. diminuta occurs upon ingestion of the parasite eggs in rat feces. The eggs then hatch and develop into cysticercoids that are capable of infecting the mammalian host and amplifying when ingested, but cannot be horizontally or vertically transmitted.Previously, we used AFLP markers to identify three major quantitative trait loci (QTL) that affected T. castaneum beetle susceptibility to H. diminuta on linkage groups LG3 [hds 4(3, L1B1.69)], LG6 [hds(6, L1A16.141)], and LG8 [hds(8, L6B2.100)]. The gene action at QTL hds(3, L1B1.69) and hds(8, L6B2.100) was overdominance...

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Porcine Toll-like receptor 1, 6, and 10 genes: Complete sequencing of genomic region and expression analysis

Cited by 47 publications

References 25 publications

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

Fine-Scale Analysis of Parasite Resistance Genes in the Red Flour Beetle, Tribolium castaneum

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