Porcine xenograft treatment of superficial partial-thickness burns in paediatric patients

Burkey, Brooke; Davis, Wellington J.; Glat, Paul M.

doi:10.12968/jowc.2016.25.sup2.s10

Cited by 26 publications

(37 citation statements)

References 16 publications

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“…With these properties, some clinicians use PX as an indicator to identify where the wound bed is adequately excised and exhibits viable tissue that is ready for autografting. 6–8 However, the use of PX is not uncontroversial because of its animal origin, and therefore, we looked for alternative materials with similar or better characteristics.…”

Section: Introductionmentioning

confidence: 99%

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Karlsson

Olofsson

Steinvall

et al. 2019

Advances in Wound Care

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Objective: The use of porcine xenograft (PX) is widely spread in burn care. However, it may cause immunologic responses and other ethical and cultural considerations in different cultures. Therefore, there is a need for alternatives. The aim of this work is to test a novel biosynthetic cellulose dressing (Epiprotect ® ) on burn patients. Approach: Charts from 38 patients with superficial burns (SBs) ( n = 18) or excised burns ( n = 20) that got biosynthetic cellulose dressing instead of PX at a national burn center during 3 years were reviewed. Time to healing, length of stay, and wound infection were extracted from the medical records. Results: SBs hospitalization time was 11 days comparable to PXs reported by others. In the excised group, median duration of hospital stay was 35 days. Time to healing was 28 days. Seven wound infections were confirmed in the superficial group (39%) and 11 infections in the excised group (61%). Patients with superficial wounds reported pain relief on application. Innovation: A dressing (17 × 21 cm) consisting of biosynthetic cellulose replacing PX. Conclusion: Outcome of treatment of SBs or temporary coverage of excised deep burns with biosynthetic cellulose is comparable to treatment with PX. However, biosynthetic cellulose has benefits such as providing pain relief on application and ethical or cultural issues with the material is nonexistent.

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Section: Introductionmentioning

confidence: 99%

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Karlsson

Olofsson

Steinvall

et al. 2019

Advances in Wound Care

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“…Preparation of the wounds before applying the epidermal templates can be considered similar in both products. After cleaning, debridement, and necrectomy [ 12 ], both products were usually applied under general anesthesia [ 20 , 21 , 31 , 32 ] or moderate-to-deep sedation [ 22 ], primarily due to the patient’s stress after the injury. The wound bed preparation technique varies among the studies: abrasion was performed using scratchpads or other metallic sponges, brushes, dermabrasion, Versajet, or dermatomes [ 21 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review

Haller¹,

Blome-Eberwein

Branski

et al. 2021

Medicina

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Background and Objectives: Porcine xenografts have been used successfully in partial thickness burn treatment for many years. Their disappearance from the market led to the search for effective and efficient alternatives. In this article, we examine the synthetic epidermal skin substitute Suprathel® as a substitute in the treatment of partial thickness burns. Materials and Methods: A systematic review following the PRISMA guidelines has been performed. Sixteen Suprathel® and 12 porcine xenograft studies could be included. Advantages and disadvantages between the treatments and the studies’ primary endpoints have been investigated qualitatively and quantitatively. Results: Although Suprathel had a nearly six times larger TBSA in their studies (p < 0.001), it showed a significantly lower necessity for skin grafts (p < 0.001), and we found a significantly lower infection rate (p < 0.001) than in Porcine Xenografts. Nonetheless, no significant differences in the healing time (p = 0.67) and the number of dressing changes until complete wound healing (p = 0.139) could be found. Both products reduced pain to various degrees with the impression of a better performance of Suprathel® on a qualitative level. Porcine xenograft was not recommended for donor sites or coverage of sheet-transplanted keratinocytes, while Suprathel® was used successfully in both indications. Conclusion: The investigated parameters indicate that Suprathel® to be an effective replacement for porcine xenografts with even lower subsequent treatment rates. Suprathel® appears to be usable in an extended range of indications compared to porcine xenograft. Data heterogeneity limited conclusions from the results.

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“…Moreover, its transparency, which offers the possibility to surveil scar formation, is very useful in the tissue regeneration field. In addition, the amniotic membrane has other interesting properties such as the capacity of decreasing exudation and wound infection, and it also accelerates epithelial regeneration, has analgesic properties, decreases heat loss and reduces scar tissue formation [44].…”

Section: Human Amniotic Membrane In Other Surgical Specialitiesmentioning

confidence: 99%

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

Tartaro

Caporossi

Virgili

et al. 2020

Regen. Eng. Transl. Med.

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Lay SummaryRecently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders such as refractory macular holes, retinal breaks and dry and wet age-related macular degeneration. Not only the hAM has proved to be an excellent tool for repairing retinal tissue, but it has also shown a promising regeneration potential. This review aims to highlight the novel use of the hAM in treating retinal diseases. Although the hAM has been used in the ocular anterior segment reconstruction for more than 60 years, in the last 2 years, we have found in literature articles showing the use of the hAM in the retinal surgery field with interesting results in terms of tissue healing and photoreceptor regeneration.

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Porcine xenograft treatment of superficial partial-thickness burns in paediatric patients

Abstract: P. M.Glat, is a paid consultant and speaker for Mölnlycke Health Care, the manufacturer of EZ Derm.

Cited by 26 publications

References 16 publications

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

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