This paper deals with pore-scale two-phase flow simulations in carbonate rock using the pore network method (PNM). This method was used to determine the rock and flow properties of three different rock samples, such as porosity, capillary pressure, absolute permeabilities, and oil–water relative permeabilities. The pore network method was further used to determine the properties of rock matrices, such as pore size distribution, topological structure, aspect ratio, pore throat shape factor, connected porosity, total porosity, and absolute permeability. The predicted simulation for the network-connected porosity, total porosity, and absolute permeability agree well with those measured experimentally when the image resolution is appropriate to resolve the relevant pore and throat sizes. This paper also explores the effect of the wettability and fraction of oil-wet pores on relative permeabilities, both in uniform and mixed wet systems.