Computationally efficient microscale models designed to simulate multi-phase flow and characterize low-porosity media are challenged in thin, highly porous materials, primarily due to large, irregular pore spaces and inability to satisfy representative elementary volume requirements. In this article, we describe the pore topology method (PTM) and explore its capabilities to characterize a set of isotropic fibrous materials and to simulate multi-phase flow. PTM is a fast, algorithmically simple method that reduces the complexity of the 3-D void space geometry to its topologically consistent medial surface and uses it as a solution domain for single-and multi-phase flow simulations. Our results in permeability calculations, pore size distribution, and quasi-static drainage and imbibition simulations are in very good agreement with other numerical methods and analytical solutions. We expect that incorporating detailed spatial information about the porous media structure into the medial surface will enable a more accurate representation of the void space structure and of physical phenomena involved in multi-phase flow, thus expanding the applicability of PTM to a broader range of porous media, including non-fibrous materials.