Based on the tight oil reservoir conditions of Lucaogou Formation in Jimusar Sag, Xinjiang, this paper conducts a full-scale characterization experiment of pore structure and designs the optimization numerical simulation of the development scheme based on the geological model combination with the fluid occurrence state. A comparative study on the development methods of tight reservoirs shows that the enhanced oil recovery effect of CO2 flooding is obviously better than that of CH4 flooding and water flooding. When the production bottom hole pressure is lower than the formation fluid saturation pressure, changing the production bottom hole pressure has little impact on the productivity of CO2 flooding in tight reservoirs. The recovery factor increases with the increase of injection rate, but when the injection rate is higher than 15,000 m³/d, the increase of oil recovery and the oil change rate decrease obviously; The complex fractures near the well can help to increase the swept volume of CO2 flooding, while the complex fractures far away from the well will cause channeling, which is not conducive to production. Combined with the occurrence state of the fluid, it is obtained that in the process of CO2 displacement, when the adsorption is considered, when the adsorption components are the same, with the increase of the adsorption capacity, the recovery factor decreases; When the adsorption capacity is constant, the higher the proportion of heavy components is, the lower the recovery factor is; With the increase of adsorption capacity, the permeability decreases more. The fluid occurrence state in tight oil reservoirs is very different from that in conventional reservoirs, and the adsorption phase accounts for a larger proportion, which seriously affects the flow capacity of the fluid during the development process. However, conventional numerical simulation rarely considers the influence of fluid occurrence state.