Porenweite von Ultrafiltern

Bechhold, H.; Schlesinger, M.; Silbereisen, K.

doi:10.1007/bf01428072

Cited by 45 publications

(12 citation statements)

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“…In order to determine the wettability of wet porous polymer structures we adapted the maximum bubble point test [39,40], which is also used as a non-destructive filter integrity test. These gas-liquid porosimetry tests have become the most widely used to determine the largest pores (> 0.1 µm) present in membrane materials [38,39].…”

Section: Wetting Behaviour Of 'Wet' Pdlla Foamsmentioning

confidence: 99%

Characterisation of ‘wet’ polymer surfaces for tissue engineering applications: Are flat surfaces a suitable model for complex structures?

Safinia

Blaker

Maquet³

et al. 2005

E-Polymers

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Tissue engineering scaffolds are 3D constructs that simulate the growth environment in vivo. The present work aims to address the question of whether thin films, i.e., flat surfaces, are a suitable model for more complex 3D structures? With this in mind a complete study of the morphology and surface chemistry of poly(D,Llactide) (PDLLA) substrates, fabricated into two different structures, is presented. The polymer structures studied include a 3D, porous, foam-like scaffold prepared by the thermally induced phase separation (TIPS) method and flat polymer thin films made by solvent casting. Based on the maximum bubble point test, a new method to assess the wettability of wet pore wall surfaces inside highly porous 3D structures was developed and tested. The maximum pore diameter determined using the maximum bubble point test for the total wetting liquids was confirmed through image analysis of scanning electron micrographs. The method allows the determination of the contact angle between the wet pore wall and a contacting liquid. The captive bubble method was employed to characterise the wettability of flat polymer films in contact with water. Both structures were further characterised using zeta-(ζ-) potential measurements to assess the surface chemistry of the polymer. The results demonstrate that PDLLA contains acidic functional groups and is hydrophobic. In order to evaluate the sensitivity of the test methods, the polymer surfaces were modified by protein adsorption using fibronectin and collagen. ζ-Potential and wettability measurements show that proteins indeed adsorb on virgin PDLLA surfaces. Protein adsorption causes the wettability of the PDLLA for water to improve. Our results strongly indicate that flat surfaces are not a suitable model for surfaces in complex 3D structures such as highly porous tissue engineering scaffolds. Such scaffolds must be characterised as a 3D system.

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Section: Wetting Behaviour Of 'Wet' Pdlla Foamsmentioning

confidence: 99%

Characterisation of ‘wet’ polymer surfaces for tissue engineering applications: Are flat surfaces a suitable model for complex structures?

Safinia

Blaker

Maquet³

et al. 2005

E-Polymers

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“…Examples of indirect techniques include liquid permeability (Palacio et al 1999), permporometry (Mey-Marom and Katz 1986), air-liquid porometry (Hernandez et al 1996), liquid-liquid porometry (Bechhold et al 1931), scanning electron microscopy (SEM) (Riedel and Spohr 1980), transmission electron microscopy (TEM) (Nakao 1994), atomic force microscopy (AFM) (Binnig et al 1986), field emission SEM (FESEM) (Dietz et al 1992), thermoporometry (Brun et al 1977), and gas adsorption-desorption (Adams et al 2013). ( Dollimore andHeal 1964, Gregg andSing 1982).…”

Section: Porosity and Tortuosity Of Te Membranes And Scaffoldsmentioning

confidence: 99%

Glucose diffusion in tissue engineering membranes and scaffolds

Suhaimi

Das

2016

Reviews in Chemical Engineering

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Tissue engineering has evolved into an exciting area of research due to its potential in regenerative medicine. The shortage of organ donors as well as incompatibility between patient and donor pose an alarming concern. This has resulted in an interest in regenerative therapy where the importance of understanding the transport properties of critical nutrients such as glucose in numerous tissue engineering membranes and scaffolds is crucial. This is due to its dependency on successful tissue growth as a measure of potential cure for health issues that cannot be healed using traditional medical treatments. In this regard, the diffusion of glucose in membranes and scaffolds that act as templates to support cell growth must be well grasped. Keeping this in mind, this review paper aims to discuss the glucose diffusivity of these materials. The paper reviews four interconnected issues, namely, (i) the glucose diffusion in tissue engineering materials, (ii) porosity and tortuosity of these materials, (iii) the relationship between microstructure of the material and diffusion, and (iv) estimation of glucose diffusivities in liquids, which determine the effective diffusivities in the porous membranes or scaffolds. It is anticipated that the review paper would help improve the understanding of the transport properties of glucose in membranes and scaffolds used in tissue engineering applications.

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“…According to Cartor equation (Bechhold et al, 1931), as expressed in Eq. 4, in order to force a pore‐filling liquid out of a pore of radius r , a minimum gas pressure difference should be applied to counteract the capillary force caused by the interface tension of the liquid where γ is the surface tension of the liquid, θ is the contact angle of the liquid on the inner surface of the pore, and r is the radius of the circular cylindrical pore.…”

Section: Theoreticalmentioning

confidence: 99%