Poroelastography: imaging the poroelastic properties of tissues

Konofagou, Elisa E.; Harrigan, Timothy P.; Ophir, Jonathan; Krouskop, Thomas A.

doi:10.1016/s0301-5629(01)00433-1

Cited by 126 publications

(116 citation statements)

References 28 publications

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“…[38][39][40][41][42][43][44][45]53 Several of the elastographic studies and related theoretical models focused on articular cartilage. 42,44,45 For example, poroelastography, 44 or elastographic imaging of poroelastic tissues, has Figure 3. Sequential images of (a) axial displacement (mm) and (b) corresponding axial strain (%) elastograms during tensile loading of the femur-ACL-tibia complex.…”

Section: Discussionmentioning

confidence: 99%

“…38,44 Axial displacements (i.e., displacements occurring orthogonal to the face of the transducer and parallel to the direction of ultrasound pulse propagation) were Figure 1. Mechanical testing of the bovine patellofemoral joints and image acquisition using an ultrasound transducer.…”

Section: Methodsmentioning

confidence: 99%

“…38 At high decorrelation noise, recorrelation techniques were employed. 44 Finally, the strain distribution was computed by differentiating the displacement map along the axial direction. For numerical differentiation, a least-squares regression method was used.…”

Section: Methodsmentioning

confidence: 99%

“…38 Ultrasound elastography in particular has been used to image the mechanical properties of articular cartilage under compression. [42][43][44][45] The objectives of this study were to use ultrasound elastography to characterize the mechanical response of ACL insertions and to image strain distributions in the ACL proper and at the ACLbone insertions. Elastography represents a novel and reliable technique suitable for evaluation of the ACL-bone interface as it permits the characterization of a relatively small region consisting of complex tissue types.…”

Section: Introductionmentioning

confidence: 99%

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Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Spalazzi

Gallina

Fung-Kee-Fung

et al. 2006

Journal Orthopaedic Research

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ABSTRACT:The anterior cruciate ligament (ACL) functions as a mechanical stabilizer in the tibiofemoral joint, and is the most commonly injured knee ligament. To improve the clinical outcome of tendon grafts used for ACL reconstructions, our long-term goal is to promote graft-bone integration via the regeneration of the native ligament-bone interface. An understanding of strain distribution at this interface is crucial for functional scaffold design and clinical evaluation. Experimental determination, however, has been difficult due to the small length scale of the insertion sites. This study utilizes ultrasound elastography to characterize the response of the ACL and ACL-bone interface under tension. Specifically, bovine tibiofemoral joints were mounted on a material testing system and loaded in tension while radiofrequency (RF) data were acquired at 5 MHz. Axial strain elastograms between RF frames and a reference frame were generated using crosscorrelation and recorrelation techniques. Elastographic analyses revealed that when the joint was loaded in tension, complex strains with both compressive and tensile components occurred at the tibial insertion, with higher strains found at the insertion sites. In addition, the displacement was greatest at the ACL proper and decreased in value gradually from ligament to bone, likely a reflection of the matrix organization at the ligament-bone interface. Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone. ß

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Spalazzi

Gallina

Fung-Kee-Fung

et al. 2006

Journal Orthopaedic Research

Self Cite

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“…Using this configuration, the lateral tissue displacements 4 in one direction were mapped under an axial compression. Based on the ultrasound 5 indentation technique [19][20][21][22] using a probe with an in-series ultrasound transducer 6 (frequency ranged from 5 to 15 MHz) and a load sensor, Zheng and coworkers have 7 developed a number of systems for, mapping one-dimensional mechanical properties of 8 articular cartilage (AC) using high frequency ultrasound (20 to 50 MHz) [23][24][25]. The 2D 9 high-frequency ultrasound elasticity imaging has only been described in theory or using 10 computer simulation in the literature [26][27] because how to properly loading on the 11 tissue samples remains as a problem.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound elastomicroscopy using water jet and osmosis loading: Potentials for assessment for articular cartilage

2006

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Research in elasticity imaging typically relies on 1 to 10 MHz ultrasound. 10 Elasticity imaging at these frequencies can provide strain maps with a resolution in the 11 order of millimeters, but this is not sufficient for applications to skin, articular cartilage, 12 or other fine structures. In this paper, we introduced two methods of noncontact 13 ultrasound elastomicroscopy for imaging the elasticity of biological soft tissues with high 14 resolutions. In the first system, the specimens were compressed using water jet 15 compression. A water jet was used to couple a focused 20 MHz ultrasound beam into the 16 specimen and meanwhile served as a "soft" indenter. Because there was no additional 17 attenuation when propagating from the ultrasound transducer to the specimen, the 18 ultrasound signal with high signal-to-noise ratio could be collected from the specimens 19 simultaneously with compressing process. The compression was achieved by adjusting 20 the water flow. The pressure measured inside the water pipe and that on the specimen 21 surface was calibrated. This system was easily to apply C-scan over sample surfaces. 22Experiments on the phantoms showed that this water jet indentation method was reliable 23 to map the tissue stiffness distribution. Results of 1D and 2D scanning on phantoms with 24 different stiffness are reported. In the second system, we used osmotic pressure caused by 25 the ion concentration change in the bathing solutions for the articular cartilage to deform 26 them. When bovine articular cartilage specimens were immerged in solutions with 27 different salt concentration, a 50 MHz focused ultrasound beam was used to monitor the 28 dynamic swelling or shrinkage process. Results showed that the system could reliably 29 map the strain distribution induced by the osmotic loading. We extract intrinsic layered 30 material parameters of the articular cartilage using a triphasic model. In addition to 31 biological tissues, these systems have potential applications for the assessment of 32 bioengineered tissues, biomaterials with fine structures, or some engineering materials. 33Further studies are necessary to fully realize the potentials of these two new methods. 34 35

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2016

Magnetic Resonance Elastography

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Poroelastography: imaging the poroelastic properties of tissues

Cited by 126 publications

References 28 publications

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Ultrasound elastomicroscopy using water jet and osmosis loading: Potentials for assessment for articular cartilage

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