Poroid hidradenoma in the hand: A case report and systematic review

Abstract

Poroid hidradenoma (PH) is a rare benign neoplasm of the skin appendages. There are currently no guidelines for its management, and little information available regarding the natural history, treatment options, or outcomes. Systematic literature review identified 19 cases of isolated PH. Mean age at presentation was 54 years. Male to female ratio was 3:1, and the majority of cases were in the head and neck region. One-third of lesions were painful or tender. Sizes varied from 0.11 × 0.9 × 0.2 cm (digit) to 6 cm (presternal region). Twelve cases were treated by surgical excision, while the remainder were biopsy specimens. Follow-up was reported in five cases, with a median follow-up of 1 year. No cases of local invasion or spread have been reported, although there was one case of possible recurrence identified 8 years after surgical excision. The presented case is the first to identify a PH on the hand, represents the smallest lesion to date, and was successfully treated by excision. We suggest that PHs be treated by excision and followed up for 6 to 12 months. Given one case of potential (but unconfirmed) recurrence, and no report of malignant transformation, we suggest that narrow margins may be appropriate.

Poroid Hidradenoma: A Two-Case Report and Literature Review

“…PH is a form of hidradenoma with eccrine differentiation according to the WHO classifications of skin tumors 1 . The age of onset ranges widely, with a peak incidence in the seventh decade of life 3 .…”

“…The most predominant site of involvement is the head and neck region, followed by the axilla, trunk, and extremities 4 . Miller et al 1 reported the systematic reviews of PH, which occur more commonly in male, in the head and neck region or limbs. Considering that these neoplasms can be generally asymptomatic or accompanied by mild tenderness, the incidence of PHs might be underestimated in the literature 5 .…”

“…Poroid hidradenoma (PH) is a benign neoplasm with eccrine differentiation 1 . Typically, PH is a solitary tender nodule with a diameter ranging from 0.5 to 2 cm.…”

Poroid hidradenoma of the scalp in a US Veteran’s Administration (VA) patient

“…Patients presenting with this condition range from ages 13 to 91 with the disease being more common in the sixth and seventh decades of life [ 6 ]. Some authors say that the incidence in males and females is about equal while others say that the male to female ratio is 3:1 [ 7 , 8 ].…”

“…In their systematic review, Miller et al. recommended 6 months to 1 year follow-up since they did find one case of possible recurrence, and they recommended marginal excisions since there are no reports of malignant transformation [ 8 ].…”