Porokeratotic eccrine ostial and dermal duct nevus associated with an 11 megabase 3p deletion

Abstract

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare eccrine hamartoma; the etiology is incompletely understood. A patient presented with congenital, widespread PEODDN. Clinical assessment, histopathologic, cytogenetic, and molecular genetic investigations on affected cells were pursued. Histopathology confirmed PEODDN, and chromosomal microarray on affected tissues identified a mosaic 3p26.3p25.3 deletion in affected tissues. This 11Mb deletion encompasses 47 OMIM genes. We propose that this and other chromosomal deletions may be implicated in some cases of PEODDN, suggesting locus heterogeneity and underscoring the importance of incorporating cytogenetic and molecular investigations into the multidisciplinary care of individuals with suspected mosaic genetic skin disorders.

Multiple yellowish pinpoint papules on bilateral palms

“…It typically starts in childhood and has histological manifestations resembling porokeratosis -parakeratotic columns with agranular cells at the base -but adds on a feature of dilated acrosyringium. 5 Other entities to consider are provided in Table 1.…”

Multiple gelbliche, punktförmige Papeln auf beiden Handflächen

“…Sie beginnen typischerweise in der Kindheit und ähneln histologisch der Porokeratose -parakeratotische Säulen mit agranulären Zellen an der Basis -, weisen aber zusätzlich dilatierte Akrosyringien auf. 5 Weitere in Frage kommende Entitäten sind in Tabelle 1 aufgeführt.…”