Porokeratotic Eccrine Ostial and Dermal Duct Nevus

Bergman, Reuven; Lichtig, Chaim; Cohen, Aurica; Friedman‐Birnbaum, Rachel

doi:10.1097/00000372-199208000-00006

Cited by 34 publications

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“…Stoof and coworkers 17 suggested that the epidermal invagination is a widely dilated keratin‐plugged acrosyringial duct which is contiguous with the dermal duct at its base. Bergmann and colleagues 18 proposed that the invagination represents an abnormal clone of epidermal cells that produces a cornoid lamella‐like column.…”

Section: Discussionmentioning

confidence: 99%

Bowen's Disease on Porokeratotic Eccrine Ostial and Dermal Duct Nevus

et al. 2007

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The authors have indicated no significant interest with commercial supporters.H amartomas with eccrine differentiation occur rarely. So far, six variants of eccrine hamartoma (eccrine nevus) have been described: purely eccrine nevus, eccrine vascular hamartoma, acrosalpingian nevus, comedo nevus of the palms, linear eccrine nevus with comedones, and porokeratoticeccrine ostial and dermal duct nevus (PEODDN). 1 PEODDN is diagnosed by histology. 2 We present a 49-year-old woman with PEODDN present since childhood that developed Bowen's disease (BD) in her lesions. Therapy of choice for both lesions was CO 2 laser therapy. Case ReportA 49-year-old woman reported the occurrence of hyperkeratotic skin lesions on her left sole since the age of 12. There was no family history of similar lesions. Therapies with topical keratolytics and calcipotriol had resulted in only temporary improvements. The permanent exertion due to the patient's occupation as physical education teacher had caused frequent inflammations in the area of the PEODDN. Physical examination revealed numerous linear keratotic papules and plaques on the left sole. For several months, one plaque had shown superficial ulceration sized 2 Â 2 cm without any tendency to heal ( Figure 1A). A diagnostic biopsy was taken from the ulcerated area.The histologic examination showed in one part a cornoid lamella associated with eccrine ducts. Another part showed parakeratosis, psoriasiform hyperplasia, full-thickness atypia of the epidermis, mitoses, and dyskeratotic cells (Figure 2), and a diFigure 1. (A) Keratotic plaques on the left sole with a superficial ulceration. (B) A 6-month postoperative checkup showed no recurrence.

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Section: Discussionmentioning

confidence: 99%

Bowen's Disease on Porokeratotic Eccrine Ostial and Dermal Duct Nevus

et al. 2007

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“…However, on staining lesion specimens with carcinoembryonic antigen (CEA), these authors noticed that only ducts within the column stained, whereas the outer wall of the invagination did not, thereby suggesting that invagination is not derived from the acrosyringium. Bergman et al (7) suggested that the invagination represents an abnormal clone of epidermal cells that produces a coronoid lamella‐like column.…”

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confidence: 99%