Under the effect of high ground stress and water-rock chemical interaction, the fractures in the damaged mudstone wound undergo a self-healing process and recover the physical and mechanical properties, which has a significant impact on the wall-rock's stability of high level radioactive waste repository and the migration of radioactive nuclide. According to the general thermodynamics and continuum damage mechanics, an internal variable describing mudstone healing properties is introduced and an elastoplastic damage-healing model reflecting mudstone deformation, damage, and self-healing evolution is put forward. This model is used to simulate the triaxial compression test of mudstone under different confining pressures, whose simulated results are compared with the test data. It is indicated that the model could embody the main mechanical properties of mudstone with the healing effect in an effective way, and the healing part of the model has a great influence on the simulated results.