Porosity and tissue integration of elastic mesh implants evaluated <i>in vitro</i> and <i>in vivo</i>

Ciritsis, Alexander; Horbach, Andreas; Staat, Manfred; Kuhl, Christiane K.; Kraemer, Nils A.

doi:10.1002/jbm.b.33877

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Meshes for abdominal surgical procedures are flexible medical devices used to treat hernias, abdominal or inguinal, by adding tension-free reinforcement that results in improved tissue integration and reparation. , Meshes have also been used as prosthetic devices for the treatment of vaginal prolapse , and urinary incontinence . In the last decade, many fundamental research has been performed on tissue compatibility, bio-integration, and mechanical properties of surgical meshes. − Also, their chemical surface functionalization has resulted in significant improvements, for example, prevention of unwanted tissue adhesion, cell adhesion/de-adhesion control features, and thermosensitive and shape memory properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Functionalized Surgical Meshes for Early Detection of Bacterial Infections

Fontana‐Escartín

Hauadi

Lanzalaco

et al. 2023

ACS Biomater. Sci. Eng.

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Isotactic polypropylene (i-PP) nonabsorbable surgical meshes are modified by incorporating a conducting polymer (CP) layer to detect the adhesion and growth of bacteria by sensing the oxidation of nicotinamide adenine dinucleotide (NADH), a metabolite produced by the respiration reactions of such microorganisms, to NAD+. A three-step process is used for such incorporation: (1) treat pristine meshes with low-pressure O 2 plasma; (2) functionalize the surface with CP nanoparticles; and(3) coat with a homogeneous layer of electropolymerized CP using the nanoparticles introduced in (2) as polymerization nuclei. The modified meshes are stable and easy to handle and also show good electrochemical response. The detection by cyclic voltammetry of NADH within the interval of concentrations reported for bacterial cultures is demonstrated for the two modified meshes. Furthermore, Staphylococcus aureus and both biofilm-positive (B+) and biofilm-negative (B-) Escherichia coli cultures are used to prove real-time monitoring of NADH coming from aerobic respiration reactions. The proposed strategy, which offers a simple and innovative process for incorporating a sensor for the electrochemical detection of bacteria metabolism to currently existing surgical meshes, holds considerable promise for the future development of a new generation of smart biomedical devices to fight against post-operative bacterial infections.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Functionalized Surgical Meshes for Early Detection of Bacterial Infections

Fontana‐Escartín

Hauadi

Lanzalaco

et al. 2023

ACS Biomater. Sci. Eng.

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“…Studies have shown that in the repair and reconstruction of abdominal wall defects, the smoothness of the mesh after placement and the tightness with the abdominal wall are the key factors to reduce adhesion. [ 16,29 ] Tomaszewska et al. found that a mesh with higher elastic strength improved the dynamic properties of healing fascia and reduced abdominal adhesion compared to traditional PP meshes.…”

Section: Resultsmentioning

confidence: 99%

“…Once the bacteria are customized to the mesh to form infection, the immune cells in the body are difficult to enter and completely remove the bacteria, and a second operation is needed to remove the mesh. [ 15,16 ] In contrast, biomaterials such as ADM and small intestinal submucosa (SIS) can be used in infected areas to reduce the risk of inflammation and increase biocompatibility and reduce the risk of adhesion formation and hernia recurrences. [ 17,18 ] In addition, hydrogels meshes in abdominal hernia repairing showed good characteristics of promoting cell growth and forming vascularization tendency.…”

Section: Introductionmentioning

confidence: 99%

“…At present, the most widely used method of making mesh is to knit polymer fibers, but the clinical application of this mesh often leads to patient's complaints including chronic pain, adhesion with adjacent organs, migration or contraction, and limited movement. [ 16,24 ] The weaving method is not convenient to prepare drug‐loaded meshes to prevent and treat postoperative inflammation. [ 25–27 ] And when special equipment is needed, weaving leads to disadvantages such as less flexibility in design and material selection.…”

Section: Introductionmentioning

confidence: 99%

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Topological Structure Design and Fabrication of Biocompatible PLA/TPU/ADM Mesh with Appropriate Elasticity for Hernia Repair

Zhang

et al. 2021

Macromolecular Bioscience

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The meshes for hernia repair result in many problems that are related to complications including chronic pain and limited movement due to inadequate mechanical strength, non‐absorbability, or low elasticity. In this study, degradable polylactic acid (PLA), synthetic thermoplastic polyurethane (TPU), and acellular dermal matrix (ADM) powders are combined to prepare a novel PLA/TPU/ADM mesh with three different topological structures (square, circular, and diamond) by 3D printing. The physicochemical properties and structural characteristics of mesh are studied, the results show that the diamond structure mesh with the pore size of 3 mm has sufficient elasticity and tensile strength, which provides the efficient mechanical strength required for hernia repair (16 N cm−1) and the value more than polypropylene(PP) mesh. Besides, in vitro and in vivo experiments demonstrate human umbilical vein endothelial cells could successfully proliferate on the PLA/TPU/ADM mesh whose biocompatibility with the host is shown using a rat model of abdominal wall defect. In conclusion, the results of this study demonstrate that the PLA/TPU/ADM mesh may be considered a good choice for hernia repair as its potential to overcome the elastic and strength challenges associated with a highly flexible abdominal wall, as well as its good biocompatibility.

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“…[23][24][25] In addition, due to the limitation of process, the selected materials are usually a synthetic polymer with poor biological performance, so they often lead to pain, adhesion, and contraction with the surrounding tissues in patients in clinical practice. [6,26] Besides, the preparation process also has direct writing, pouring and so on. Although these processes can effectively prepare patches, they have shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Designing Double‐Layer Multimaterial Composite Patch Scaffold with Adhesion Resistance for Hernia Repair

Zhang

et al. 2022

Macromolecular Bioscience

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Hernia repair mesh is associated with a number of complications, including adhesions and limited mobility, due to insufficient mechanical strength and nonresorbability. Among them, visceral adhesions are one of the most serious complications of patch repair. In this study, a degradable patch with an antiadhesive layer is prepared for hernia repair by 3D printing and electrospinning techniques using polycaprolactone, polyvinyl alcohol, and soybean peptide (SP). The study into the physicochemical properties of the patch is found that it has adequate mechanical strength requirements (16 N cm −1 ) and large elongation at break, which are superior than commercial polypropylene patches. In vivo and in vitro experiments show that human umbilical vein endothelial cells proliferated well on composite patches, and showed excellent biocompatibility with the host and little adhesion through a rat abdominal wall defect model. In conclusion, the results of this study show that composite patch can effectively reduce the occurrence of adhesions, while the addition of SP in the patch further enhances its biocompatibility. It is believed that a regenerative biological patch with great potential in hernia repair provides a new strategy for the development of new biomimetic biodegradable patches.

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Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo

Abstract: The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.

Cited by 11 publications

References 24 publications

Preparation and Characterization of Functionalized Surgical Meshes for Early Detection of Bacterial Infections

Preparation and Characterization of Functionalized Surgical Meshes for Early Detection of Bacterial Infections

Topological Structure Design and Fabrication of Biocompatible PLA/TPU/ADM Mesh with Appropriate Elasticity for Hernia Repair

Designing Double‐Layer Multimaterial Composite Patch Scaffold with Adhesion Resistance for Hernia Repair

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