Porous and spherical ethyl cellulose fine particles produced by ternary system-based emulsion castings

Takezaki, Hiroshi; Otsubo, Takahiko; Echigo, Yuji; Kamiya, Hidehiro; Okada, Yohei

doi:10.1016/j.powtec.2021.10.024

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Ideally, the external oil phase should possess additional skin penetration enhancement properties to facilitate dermal drug delivery [45]. However, the art of creating an oil-in-oil (O/O) emulsion lies in the mixing of two immiscible lipophilic components to maintain the separation of an internal and external oil phase [2,46]. Therefore, it would be best to employ a 'lipophilic oil' as well as a more 'hydrophilic oil' into a single SDEDDS.…”

Section: Oil Immiscibility Studiesmentioning

confidence: 99%

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

van Staden,

Haynes,

Viljoen

2023

Pharmaceuticals

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Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux as mediated by P-glycoprotein, enhanced lymphatic drug uptake, improved control over plasma concentration profiles of drugs, enhanced stability, and drug loading efficiency. Interest in dermal spontaneous emulsions has increased, given that systems have been reported to deliver drugs across mucus membranes, as well as the outermost layer of the skin into the underlying layers. The background and development of a double spontaneous emulsion incorporating four anti-tubercular drugs, clofazimine (CFZ), isoniazid (INH), pyrazinamide (PZY), and rifampicin (RIF), are described here. Our methods involved examination of oil miscibility, the construction of pseudoternary phase diagrams, the determination of self-emulsification performance and the emulsion stability index of primary emulsions (PEs), solubility, and isothermal micro calorimetry compatibility and examination of emulsions via microscopy. Overall, the potential of self-double-emulsifying drug delivery systems (SDEDDSs) as a dermal drug delivery vehicle is now demonstrated. The key to success here is the conduct of preformulation studies to enable the development of dermal SDEDDSs. To our knowledge, this work represents the first successful example of the production of SDEDDSs capable of incorporating four individual drugs.

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Section: Oil Immiscibility Studiesmentioning

confidence: 99%

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

van Staden,

Haynes,

Viljoen

2023

Pharmaceuticals

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“…Substantial efforts have been devoted to the design and application of nonaqueous emulsions, and tremendous application potential has emerged, [5][6][7][8][9][10][11] especially for the polymerization of water-sensitive monomers/catalysts [12][13][14][15][16][17][18] and the encapsulation of hygroscopic materials. [19][20][21][22][23] Even so, nonaqueous emulsions are far less developed because of the difficulty of finding or designing suitable surfactant/stabilizers.…”

Section: Introductionsmentioning

confidence: 99%

Tailor-made urethane-linked alkyl-celluloses: a promising stabilizer for oil-in-oil Pickering emulsions

et al. 2022

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Highly selective adsorption and biodegradation of emulsified oil by microorganisms embedded in SiO2 hollow sphere bioreactor

Qu,

Chen,

Hasi

et al. 2024

Separation and Purification Technology

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Porous and spherical ethyl cellulose fine particles produced by ternary system-based emulsion castings

Cited by 6 publications

References 26 publications

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

Tailor-made urethane-linked alkyl-celluloses: a promising stabilizer for oil-in-oil Pickering emulsions

Highly selective adsorption and biodegradation of emulsified oil by microorganisms embedded in SiO2 hollow sphere bioreactor

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