Porous and strong bioactive glass (13–93) scaffolds fabricated by freeze extrusion technique

Huang, Tieshu; Rahaman, Mohamed N.; Doiphode, Nikhil D.; Leu, Ming-Chuan; Bal, B. Sonny; Day, Delbert E.; Liu, X.

doi:10.1016/j.msec.2011.06.004

Cited by 92 publications

(36 citation statements)

References 30 publications

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“…FEF was used to make 13-93 glass scaffolds with 50% porosity and with pores and struts of equal size (300 lm), giving a compressive strength of 140 MPa [200,201]. A bioactive glass-polymer paste (particles <15 lm) was extruded and deposited layer by layer in a cold environment.…”

Section: Bioactive Glass Scaffolds From Additive Manufacturing Technimentioning

confidence: 99%

Reprint of: Review of bioactive glass: From Hench to hybrids

2015

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Section: Bioactive Glass Scaffolds From Additive Manufacturing Technimentioning

confidence: 99%

Reprint of: Review of bioactive glass: From Hench to hybrids

2015

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“…As of today, 3D scaffold obtained via thermal bonding [14][15] and polymer foam replication [16][17][18] can be mainly classified as glass-ceramic. While some researchers have developed scaffolds with high mechanical properties [19], some typical bioactive glasses, even deprived of crystalline phase, do not fully resorb in-vivo. Indeed, taken as example, when the glass S53P4 was placed in benign bone tumor, a randomized 14-years follow up study concluded on the reminiscence of glass particles within the surgical site [20].…”

Section: Introductionmentioning

confidence: 99%

Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineering

et al. 2017

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Typical silicate bioactive glasses are known to crystallize readily during the processing of porous scaffolds. While such crystallization does not fully suppress the bioactivity, the presence of significantly large amounts of crystals leads to a decrease in the rate of reaction of the glass and an uncontrolled release of ions. Furthermore, due to the non-congruent dissolution of silicate glasses, these materials have been shown to remain within the surgical site even 14 years postoperation. Therefore, a need for bioactive materials that can dissolve with higher conversion rates and more effectively are required. Within this work, boron was introduced, in the FDA approved S53P4 glass, at the expense of SiO2. The crystallization and sintering-ability of the newly developed glasses were investigated by differential thermal analysis. All the glasses were found to crystallize primarily from the surface, and the crystal phase precipitating was dependent upon the quantity of B2O3 incorporated. The rate of crystallization was found to be lower for the glasses were 25, 50 and 75 % of the SiO2 was replaced with B2O3. These glasses were further sintered into porous scaffolds using simple heat sintering. The impact of glass particles size and heat treatment temperature on the scaffolds porosity and average pore size was investigated. Scaffolds with porosity ranging from 10 to 60 % with compressive strength ranging from 1 to 35 MPa, were produced. The scaffolds remained amorphous during processing and their ability to rapidly precipitate hydroxycarbonated apatite was maintained. This is of particular interest in the field of tissue engineering as the scaffolds degradation and reaction was generally faster and offers higher controllability as opposed to current partially/fully crystallized scaffolds obtained from the FDA approved bioactive glasses. IntroductionAs of today, autografts are still the gold standard for the repair of large bone defects. However, with the aging and growing population, the number of surgical intervention to regenerate bone defects are increasing. The limited supply and patient site morbidity is a well-known disadvantage and problem [1][2]. Allografts are an option. However, the limited tissue bank as well as the higher risk for infection and cellular and humoral immune reactions limits their usage [3]. The quest for synthetic biomaterials to replace the autografts is more than two decades old. However, as of today no materials have shown as promising a result as autografts. Q. Chen et al. have reported the optimum characteristic that the synthetic materials should have to find great potential as bone grafts [4]. The bone graft should be a 3D construct (3D scaffold) not only biocompatible, but ultimately biodegradable and osteoconductive with highly interconnected porosity. Pore size should be no less than 100 µm to allow cell and fluid penetration as well as angiogenesis. In general, interconnected pores of at least 100 µm and an open porosity of over 50% is considered the minimum requirement for ti...

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“…Bioactive glass (13-93 or S53P4) scaffolds created with a grid-like microstructure (porosity ∼ 50%; pore width ∼ 300 µm) by additive manufacturing (3D printing) techniques have shown even higher compressive strength, comparable to human cortical bone (100-150 MPa) [20][21][22][23][24][25]. These scaffolds were shown to have a microstructure conducive to infiltration with new bone [26,27], elicited no adverse biological reaction over a long-term period in vivo (6 months) [26,28], and healed critical-size segmental defects in small and large rodents [29,30].…”

Section: Introductionmentioning

confidence: 99%

Review - bioactive glass implants for potential application in structural bone repair

Rahaman¹,

Xiao²,

Huang³

2017

Biomedical Glasses

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Bioactive glass particles and weak scaffolds have been used to heal small contained bone defects but an unmet challenge is the development of bioactive glass implants with the requisite mechanical reliability and in vivo performance to heal structural bone defects. Inadequate mechanical strength and a brittle mechanical response have been key concerns in the use of bioactive glass scaffolds in structural bone repair. Recent research has shown the capacity to create strong porous bioactive glass scaffolds and the ability of these scaffolds to heal segmental bone defects in small and large rodents at a rate comparable to autogenous bone grafts. Loading these strong porous scaffolds with bone morphogenetic protein-2 can significantly enhance their ability to regenerate bone. Recent work has also shown that coating the external surface of strong porous scaffolds with an adherent biodegradable polymer can dramatically improve their load-bearing capacity in flexural loading and their work of fracture (a measure of toughness). These tough and strong bioactive glass-polymer composites with an internal architecture conducive to bone infiltration could provide optimal synthetic implants for structural bone repair. Keywords:Bioactive glass for structural bone repair; bioactive glass composites; mechanical and in vivo evaluation of bioactive glass scaffolds

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Porous and strong bioactive glass (13–93) scaffolds fabricated by freeze extrusion technique

Cited by 92 publications

References 30 publications

Reprint of: Review of bioactive glass: From Hench to hybrids

Reprint of: Review of bioactive glass: From Hench to hybrids

Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineering

Review - bioactive glass implants for potential application in structural bone repair

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