Porous Au/AAO: A simple and feasible SERS substrate for dynamic monitoring and mechanism analysis of DNA oxidation

Ordered Anodic Aluminum Oxide-Based Nanostructures for Surface-Enhanced Raman Scattering: A Review

“…118 Furthermore, the 0D nanoarray substrates based on AAO templates display stable and repeatable SERS signals when used to trap molecules because of the uniform distribution of nanopores of the AAO templates. 75 The tunable nanopore structural parameters, such as the position, size, and shape, of AAO templates combine active materials synthesized by different technologies and also make SERS substrates prepared by AAO-template-assisted approaches have multiple hot spots, leading to largely enhanced SERS signals. 85 Based on the superior signal enhancement effect and signal stability and reproducibility, many researchers have fabricated diverse 0D nanoarrays substrates based on AAO templates and explored their performance in SERS.…”

“…Another porous Au/ AAO SERS substrate was applied to monitor the dynamic oxidation of DNA samples with a relative standard deviation (RSD) of 12.20%, confirming the accuracy of SERS sensing. 75 To improve the reproducibility of 3D AAO-based SERS substrates, Lin et al proposed a strategy of incorporating an internal standard (IS) into the SERS substrate. 147 In detail, Au nanobipyramids/AAO nanostructures were employed as SERS substrates and modified with IS to calibrate fluctuations of SERS signals, which were susceptible to variations in laser intensity, ambient temperature, and solution conditions.…”

“…In comparison to traditional SERS substrates characterized by randomly rough surface metals or uncontrollable aggregation of metal nanoparticles, ordered nanostructure-based SERS substrates present sensitive, stable, and reproducible Raman signal outputs. , The AAO template-based technique has found great potentials in creating ordered nanostructure arrays specifically for SERS substrates, offering well-defined structures, morphologies, and compositions. − Highly ordered AAO templates with desired structural parameters, including pore diameters, interpore spacing, and template thickness, can be precisely engineered by controlling anodization conditions, such as applied voltage, anodization temperature, and duration as well as the type and concentration of the electrolyte. , Numerous SERS substrates featuring highly ordered nanoarray structures, including arrays of nanodots, nanorods, nanotubes, and nanowires coupled with various SERS-sensitive materials, such as noble metals and semiconductor materials (Figure e), are able to be achieved through AAO templates combined with material preparation methods, like physical vapor deposition, atomic layer deposition (ALD), and electrochemical deposition. − …”

“…For these 0D nanoarray substrates based on AAO templates, a simple approach is to embed metal nanoparticles into nanochannels of AAO templates, which can avoid random aggregation of these nanoparticles during SERS testing . Furthermore, the 0D nanoarray substrates based on AAO templates display stable and repeatable SERS signals when used to trap molecules because of the uniform distribution of nanopores of the AAO templates . The tunable nanopore structural parameters, such as the position, size, and shape, of AAO templates combine active materials synthesized by different technologies and also make SERS substrates prepared by AAO-template-assisted approaches have multiple hot spots, leading to largely enhanced SERS signals .…”

LSPR Tunable Ag@PDMS SERS Substrate for High Sensitivity and Uniformity Detection of Dye Molecules

“…For example, Kozhina et al used a cost-effective template-assisted electrodeposition method to grow metal nanowires (NWs) in polymer trace etching film (TM) holes to prepare SERS substrates [ 21 , 22 ]. Xiang et al obtained an Au/AAO SERS substrate by sputtering a gold nano-film onto the porous anodic aluminum oxide (AAO) surface [ 23 ]. According to the effective medium theory (EMT), the porous structure had excellent SERS performance because the effective refractive index gradient was formed when the incident light from air irradiated to the substrate surface, which leads to the light propagation path being prolonged and ultimately realized the light-trapping effect [ 24 ].…”