Porous-based rheological model for tissue fluidisation

Asadipour, Nina; Trepat, Xavier; Muñoz, José J.

doi:10.1016/j.jmps.2016.07.002

Cited by 5 publications

(11 citation statements)

References 40 publications

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“…On the other hand, for Muñoz's active element, the inelastic part of the external power will be used to overcome the resistance of the cytoskeleton filaments γ to adapt to the new configuration imposed by the external strain. The active model proposed by Muñoz has been generalized to two-dimensional/three-dimensional continuum models [111] and also integrated into discrete models such as cell-centred [112], vertex [113] and cell-centred/vertex hybrid [109,110] approaches. By incorporating a porosity parameter representing the density of polymers in the cell cytoskeleton, the continuum model proposed by Asadipour et al can also replicate the immediate fluidization in cells in response to transient strains and the subsequent gradual stiffening [111].…”

Section: Model Proposed By Muñoz Et Almentioning

confidence: 99%

Active viscoelastic models for cell and tissue mechanics

Tajvidi Safa,

Huang,

Kabla

et al. 2024

R. Soc. Open Sci.

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Living cells are out of equilibrium active materials. Cell-generated forces are transmitted across the cytoskeleton network and to the extracellular environment. These active force interactions shape cellular mechanical behaviour, trigger mechano-sensing, regulate cell adaptation to the microenvironment and can affect disease outcomes. In recent years, the mechanobiology community has witnessed the emergence of many experimental and theoretical approaches to study cells as mechanically active materials. In this review, we highlight recent advancements in incorporating active characteristics of cellular behaviour at different length scales into classic viscoelastic models by either adding an active tension-generating element or adjusting the resting length of an elastic element in the model. Summarizing the two groups of approaches, we will review the formulation and application of these models to understand cellular adaptation mechanisms in response to various types of mechanical stimuli, such as the effect of extracellular matrix properties and external loadings or deformations.

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Section: Model Proposed By Muñoz Et Almentioning

confidence: 99%

Active viscoelastic models for cell and tissue mechanics

Tajvidi Safa,

Huang,

Kabla

et al. 2024

R. Soc. Open Sci.

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“…where γ is the remodelling rate, and ε is the elastic strain used in (7). It has been previously shown that such a rheological model reproduces Maxwell viscoelastic behaviour [27], and that it can be employed to simulate tissue fluidisation [4,20] or cell cortex response in embryogenesis [10,12]. Since cells exhibit inherent contractility exerted at the cortex cross-linked structure [31], we modify the evolution law in (9) aṡ…”

Section: Rheological Modelmentioning

confidence: 99%

Junctional and cytoplasmic contributions in wound healing

Mosaffa

Tetley

Ferran

et al. 2020

J. R. Soc. Interface.

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Wound healing is characterized by the re-epitheliation of a tissue through the activation of contractile forces concentrated mainly at the wound edge. While the formation of an actin purse string has been identified as one of the main mechanisms, far less is known about the effects of the viscoelastic properties of the surrounding cells, and the different contribution of the junctional and cytoplasmic contractilities. In this paper, we simulate the wound healing process, resorting to a hybrid vertex model that includes cell boundary and cytoplasmic contractilities explicitly, together with a differentiated viscoelastic rheology based on an adaptive rest-length. From experimental measurements of the recoil and closure phases of wounds in the Drosophila wing disc epithelium, we fit tissue viscoelastic properties. We then analyse in terms of closure rate and energy requirements the contributions of junctional and cytoplasmic contractilities. Our results suggest that reduction of junctional stiffness rather than cytoplasmic stiffness has a more pronounced effect on shortening closure times, and that intercalation rate has a minor effect on the stored energy, but contributes significantly to shortening the healing duration, mostly in the later stages.

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“…where γ is the remodelling rate, and ε is the elastic strain used in (7). It has been 111 previously shown that such a rheological model reproduces Maxwell viscoelastic 112 behaviour [16], and that it can be employed to simulate tissue fluidisation [19,26] or cell 113 cortex response in embryogenesis [17,27].…”

Section: Rheological Model 110mentioning

confidence: 99%

“…However, both medial and junctional 25 cortices are differentiated in conjunction with a viscoelastic rheological model. 26 The tailored vertex model and the comparison with the experimental rate of tissue 27 recoil will enable us to calibrate the material viscoelastic properties. The employed 28 rheological model resorts to a Maxwell-like viscous model where the rest-length is able 29 to dynamically adapt [16].…”

mentioning

confidence: 99%

Junctional and cytoplasmatic contributions in wound healing

Mosaffa

Tetley

Ferran

et al. 2020

Preprint

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Wound healing is characterised by the re-epitheliation of a tissue through the activation of contractile forces concentrated mainly at the wound edge. While the formation of an actin purse string has been identified as one of the main mechanisms, far less is known about the effects of the viscoelastic properties of the surrounding cells, and the different contribution of the junctional and cytoplasmic contractilities.In this paper we simulate the wound healing process, resorting to a hybrid vertex model that includes cell boundary and cytoplasmatic contractilities explicitly, together with a differentiated viscoelastic rheology based on an adaptive rest-length. From experimental measurements of the recoil and closure phases of wounds in the Drosophila wing disc epithelium, we fit tissue viscoelastic properties. We then analyse in terms of closure rate and energy requirements the contributions of junctional and cytoplasmatic contractilities.Our results suggest that reduction of junctional stiffness rather than cytoplasmatic stiffness has a more pronounced effect on shortening closure times, and that intercalation rate has a minor effect on the stored energy, but contributes significantly to shortening the healing process, mostly in the later stages. Author summaryWe simulate the wound healing process of epithelia in the absence of substrate. By analysing the recoil process we are able to fit the viscoelastic properties of the monolayer, and study the influence of contractility at junctions and at the interior polymer network. We numerically simulate the whole wound opening and closure process, and inspect which mechanism has a more pronounced effect in terms of energy barrier and wound closure rate. We conclude that while junctional stiffness seems to be more effective than bulk stiffness at speeding up the closure, the increase of intercalation process is the mechanism with the lowest energy cost. February 17, 2020 1/17 1 Wound healing is a fundamental process for maintaining integrity and functionality 2 in epithelia, tissues, and organisms [1]. The most accepted mechanisms for wound 3 closure are Rac-dependent crawling using cell protrusions [2], and the formation of a 4 contractile supra-cellular actomyosin cable at the wound edge (purse-string 5 mechanism) [3]. However, in embryonic and larval tissues, either the elastic substrate is 6not present or no crawling has been observed. In these cases, the first mechanism is 7 absent and closure relies mostly on the actomyosin cable and cell-cell interactions [4], 8 which is the focus of our study in this article. 9Extensive analyses have reported the key mechanical factors affecting wound closure. 10 The effects of myosin heterogeneity [5,6], purse-string assembly rate [6], or tissue 11 fluidity [4] have been studied. However, far less is known about the contribution of 12 junctional and cell medial contractility and stiffness during closure, and the energy 13 barrier that they may impose during the intercalation process. We here simulate 14 wounding of the Drosoph...

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Porous-based rheological model for tissue fluidisation

Cited by 5 publications

References 40 publications

Active viscoelastic models for cell and tissue mechanics

Active viscoelastic models for cell and tissue mechanics

Junctional and cytoplasmic contributions in wound healing

Junctional and cytoplasmatic contributions in wound healing

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