Porous Bioactive Nanostructured Scaffolds for Bone Regeneration: A Sol-Gel Solution

Mahony, Oliver; Jones, Julian R.

doi:10.2217/17435889.3.2.233

Cited by 32 publications

(20 citation statements)

References 58 publications

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“…[20][21][22] An additional advantage is that nanocomposties will provide greater control over degradation.…”

Section: 19mentioning

confidence: 99%

“…15 Synthetic bone grafts (also called alloplasts) such as hydroxyapatite, Bioglass ®4 and tricalcium posphates 2 are also currently used, but are brittle, their degradation rate is difficult to tailor and clinicians cannot easily cut them to shape. Therefore a real need exists for a new synthetic bone 20 graft material that better matches the properties of bone.…”

Section: Introduction Bone Graftsmentioning

confidence: 99%

“…For regenerating bone, γ-PGA is an alternative to polyesters such as PLA or PGA that degrade by hydrolysis (random chain scission), which can cause rapid loss of mechanical properties 20 once degradation begins. In contrast γ-PGA degrades enzymatically from the surface.…”

mentioning

confidence: 99%

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Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration

Poologasundarampillai

Ionescu

Tsigkou

et al. 2010

J. Mater. Chem.

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Bone grafts are commonly used to regenerate bone in defect sites resulting from disease or trauma but there is clinical need for artificial materials that will be readily available and reduce pain and recovery time for the patient. Current artificial bone graft materials are bioactive ceramics and glasses, which are too brittle for bone defects that experience cyclic load. The synthesis of a new nanocomposite material is described that has the potential of being a tough off-the-shelf artificial bone graft that can regenerate a bone defect and have enough flexibility to press-fit into place. The poly(γ-glutamic acid)/bioactive silica hybrid material with composition 40 wt% organic and 60 wt% bioactive inorganic (composition 70 mol% SiO 2 and 30 mol% CaO) was synthesised using a sol-gel route. The potential advantage of a hybrid material over conventional composites is the molecular scale interactions between the bioactive inorganic and the tough degradable organic. The organic and inorganic chains were covalently crosslinked using an organosilane that has an organic functionality to bond to poly(γ-glutamic acid) (γ-PGA) and an alkoxysilane group that condenses with the inorganic phase. The covalent cross-linking (class II hybrid)is required to control the dissolution and improve mechanical properties of the material. The two key variables, the concentration of cross-linking agent and the addition of calcium, were investigated by 29 Si solid-state NMR and electron microscopy. The hybrid materials were bioactive in simulated body fluid (SBF) with a hydroxy carbonate apatite (HCA) layer detected after immersion for 72 h. The hybrid material favours cell attachment and is not cytotoxic as demonstrated by culture of the osteosarcoma cell line SaOs-2 on the material for 4 days. This journal is

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“…[20][21][22] An additional advantage is that nanocomposties will provide greater control over degradation.…”

Section: 19mentioning

confidence: 99%

Section: Introduction Bone Graftsmentioning

confidence: 99%

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Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration

Poologasundarampillai

Ionescu

Tsigkou

et al. 2010

J. Mater. Chem.

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“…Allografts/xenografts are still related with risk of disease transmission or immune rejection, as well as with reduced biological properties following sterilization and storage, (6), and thus have limited usage. Synthetic graft substitutes include porous metals, (7), bioactive glasses, (8), glass-ceramics, (9), synthetic polymers (e.g. synthetic hydroxyapatite), (10), and calcium phosphates/sulphates (11).…”

Section: Introductionmentioning

confidence: 99%

Histological Study of the Effect of Bioactive Glass on Tibial Bone Repair in Rats

Salam¹

2015

IJCDA

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Abstract:The main goal of this study was to histologically evaluate the healing of surgically created defects on the tibiae of adult rats after implantation of bioactive glass. Twenty adult Wistar rats (body weight of 300g) were divided into two groups: bioglass treated group (n=10) and control group (n=10). Unicortical bone defects with 3-mm diameter were performed in both tibiae of the animals and filled with bioglass particles. The rats were then sacrificed at 14, 30 , 60 and 90 days, and the tissues were prepared for histological processing, sectioning, and staining with hematoxylin and eosin, as well as Mallory trichrome, and analyzed under light microscope. Within 7-14 days, both groups presented connective tissue septa with new bone formation, more intense in bioglass treated group. In the subsequent periods (30, 60 and 90 days), these groups presented more mature bone tissue around the glass particles. Bone trabeculae formed in all experimental periods were juxtaposed to the glass particles. It can be concluded that bioglass materials promoted bone formation over the entire extension of the defect, independently of the size of the granules, thus confirming their biological osteoconductive property.

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“…10,11 Inflammation, mainly caused by microbial infection, sets in within minutes of a skin injury. In such cases, silver (Ag) ions can have significant antimicrobial effects.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial hemostatic dressings with nanoporous bioglass containing silver

Liang²,

Tong³

et al. 2012

IJN

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Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m 2 /g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS's clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.

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Porous Bioactive Nanostructured Scaffolds for Bone Regeneration: A Sol-Gel Solution

Cited by 32 publications

References 58 publications

Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration

Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration

Histological Study of the Effect of Bioactive Glass on Tibial Bone Repair in Rats

Antibacterial hemostatic dressings with nanoporous bioglass containing silver

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