Porous carbon films decorated with silver nanoparticles as a sensitive SERS substrate, and their application to virus identification

Luo, Zhihui; Chen, Lina; Liang, Chunjie; Wei, Qilin; Chen, Yuan; Wang, Jing

doi:10.1007/s00604-017-2369-y

Cited by 29 publications

(15 citation statements)

References 30 publications

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“…As illustrated in Figure 5b, the linear equation was y = 9537.74 + 863.95x (x represented the logarithm of concentration, y represented the Raman intensity at 1587 cm −1 ). As shown in Figure 5a, the limit of detection (LOD) of CV was about 1 × 10 −11 mol/L, which was comparable to the previous results (from 10 −14 mol/L to 10 −6 mol/L) [48,49]. Therefore, the SERS substrate shows good sensitivity for detecting CV molecules at low concentration.…”

Section: Resultssupporting

confidence: 85%

Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

Zhang

Jiao

2019

Nanomaterials

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The integration of surface-enhanced Raman scattering (SERS) and surface-enhanced fluorescence (SEF) has attracted increasing interest and is highly probable to improve the sensitivity and reproducibility of spectroscopic investigations in biomedical fields. In this work, dual-mode SERS and SEF hierarchical structures have been developed on a single bio-metallic substrate. The hierarchical structure was composed of micro-grooves, nano-particles, and nano-ripples. The crystal violet was selected as reporter molecule and both the intensity of Raman and fluorescence signals were enhanced because of the dual-mode SERS−SEF phenomena with enhancement factors (EFs) of 7.85 × 105 and 14.32, respectively. The Raman and fluorescence signals also exhibited good uniformity with the relative standard deviation value of 2.46% and 5.15%, respectively. Moreover, the substrate exhibited high sensitivity with the limits of detection (LOD) as low as 1 × 10−11 mol/L using Raman spectroscopy and 1 × 10−10 mol/L by fluorescence spectroscopy. The combined effect of surface plasmon resonance and “hot spots” induced by the hierarchical laser induced periodical surface structures (LIPSS) was mainly contributed to the enhancement of Raman and fluorescence signal. We propose that the integration of SERS and SEF in a single bio-metallic substrate is promising to improve the sensitivity and reproducibility of detection in biomedical investigations.

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Section: Resultssupporting

confidence: 85%

Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

Zhang

Jiao

2019

Nanomaterials

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“…Considering all the factors, the US Food and Drug Administration (FDA) has deduced that negative real-time RT-PCR test result does not necessarily substantiate the absence of SARS-CoV-2 infection and shall not be the only factor in patient management decisions. 87,88 Re-testing should be taken into consideration in consultation with public health authorities. 89…”

Section: Real-time Rt-pcrmentioning

confidence: 99%

COVID-19 Pandemic: Review of Contemporary and Forthcoming Detection Tools

Oishee¹,

Ali²,

Jahan³

et al. 2021

IDR

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Recent severe acute respiratory syndrome 2 (SARS-CoV-2) known as COVID-19, presents a deadly challenge to the global healthcare system of developing and developed countries, exposing the limitations of health facilities preparedness for emerging infectious disease pandemic. Opportune detection, confinement, and early treatment of infected cases present the first step in combating COVID-19. In this review, we elaborate on various COVID-19 diagnostic tools that are available or under investigation. Consequently, cell culture, followed by an indirect fluorescent antibody, is one of the most accurate methods for detecting SARS-CoV-2 infection. However, restrictions imposed by the regulatory authorities prevented its general use and implementation. Diagnosis via radiologic imaging and reverse transcriptase PCR assay is frequently employed, considered as standard procedures, whereas isothermal amplification methods are currently on the verge of clinical introduction. Notably, techniques such as CRISPR-Cas and microfluidics have added new dimensions to the SARS-CoV-2 diagnosis. Furthermore, commonly used immunoassays such as enzyme-linked immunosorbent assay (ELISA), lateral flow immunoassay (LFIA), neutralization assay, and the chemiluminescent assay can also be used for early detection and surveillance of SARS-CoV-2 infection. Finally, advancement in the next generation sequencing (NGS) and metagenomic analysis are smoothing the viral detection further in this global challenge.

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“…4C). Porcine circovirus type 2 (PCV2), porcine parvovirus (PPV) and porcine pseudorabies virus (PRV) were detected by SERS based on a porous carbon substrate decorated with silver nanoparticles (Luo et al, 2017). The LOD of these three are as low as 1 � 10 7 copies mL À 1 .…”

Section: Potential Portable Biosensorsmentioning

confidence: 99%

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

Cui

Zhou

2020

Biosensors and Bioelectronics

327

251

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Porous carbon films decorated with silver nanoparticles as a sensitive SERS substrate, and their application to virus identification

Cited by 29 publications

References 30 publications

Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

COVID-19 Pandemic: Review of Contemporary and Forthcoming Detection Tools

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

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