Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for real-time detection of lactic acid from cancer cell metabolism

Bi, Yulong; Ye, Lihui; Mao, Yu; Wang, Lu; Qu, Hao; Liu, Jian; Zheng, Lei

doi:10.1016/j.bios.2019.04.039

Cited by 39 publications

(23 citation statements)

References 47 publications

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“…Among them, phenazine methosulfate (PMS) transfers hydrogen to reduce yellow nitrotetrazolium (NBT) into purple NBTH 2 (Figure 3 d). [24] Expectedly, the intracellular lactate content was relatively enhanced for FePt@FeO x @TAM‐PEG treated cells, while no obvious increase of lactate for FePt@FeO x ‐PEG group (Figure 3 e).…”

Section: Resultsmentioning

confidence: 87%

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

et al. 2021

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Chemodynamic therapy is an emerging tumor therapeutic strategy. However, the anticancer effects are greatly limited by the strong acidity requirements for effective Fenton‐like reaction, and the inevitably “off‐target” toxicity. Herein, we develop an acidity‐unlocked nanoplatform (FePt@FeOx@TAM‐PEG) that can accurately perform the high‐efficient and tumor‐specific catalysis for anticancer treatment, through dual pathway of cyclic amplification strategy. Notably, the pH‐responsive peculiarity of tamoxifen (TAM) drug allows for the catalytic activity of FePt@FeOx to be “turn‐on” in acidic tumor microenvironments, while keeping silence in neutral condition. Importantly, the released TAM within cancer cells is able to inhibit mitochondrial complex I, leading to the upregulated lactate content and thereby the accumulated intracellular H+, which can overcome the intrinsically insufficient acidity of tumor. Through the positive feedback loop, large amount of active FePt@FeOx nanocatalyzers are released and able to access to the endogenous H2O2, exerting the improved Fenton‐like reaction within the more acidic condition. Finally, such smart nanoplatform enables self‐boosting generation of reactive oxygen species (ROS) and induces strong intracellular oxidative stress, leading to the substantial anticancer outcomes in vivo, which may provide a new insight for tumor‐specific cascade catalytic therapy and reducing the “off‐target” toxicity to surrounding normal tissues.

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Section: Resultsmentioning

confidence: 87%

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

et al. 2021

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“…When the temperature increased from 260°C to 348°C, the absorption peaks changed. The change was because polymerization reactions in the solid phase resulted in coke formation resulting in a low CO 2 10,31 release. As the temperature continued to rise above 390°C, the absorbance was considerably reduced, attributed to the termination of polymerization reactions 31,32 …”

Section: Resultsmentioning

confidence: 99%

“…In this paper, we researched the thermal degradation characteristics of CHA by analyzing the TG and DTG curves. The primary devolatilization step of CHA occurred between 200 C and 500 C. The differences between TG and DTG and the changes in the pyrolysis products were analyzed at selected heating rates (10,20,30, and 40 C/min). The study indicated that as the heating rate increases, the pyrolysis rate also increases.…”

Section: Discussionmentioning

confidence: 99%

“…This has shown great application potential in electrochemical detection, energy storage, and other fields. 10 And the algal biochar also showed a stronger electrochemical response and better adsorption of redox mediators than graphite plate electrode. 11 In this article, we innovatively proposed to used the biochar from the pyrolysis of Chaohu algae as an electrode functionalizing material and further evaluated the detection performance of the modified electrode.…”

Section: Introductionmentioning

confidence: 98%

“…Through proper pretreatment or doping, the effect is equivalent or even better than that of commercially available carbon materials. This has shown great application potential in electrochemical detection, energy storage, and other fields 10 . And the algal biochar also showed a stronger electrochemical response and better adsorption of redox mediators than graphite plate electrode 11 .…”

Section: Introductionmentioning

confidence: 99%

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From green tide to biochar: Thermal decomposition kinetics and TG‐FTIR study of microalgae from Chaohu Lake

Wang

et al. 2020

Int J Energy Res

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Every summer, algal bloom occurs in Chaohu Lake, causing the death of large numbers of aquatic animals, water pollution, and environmental pollution. Although Chaohu algae (CHA) is a pollutant, it represents a possible renewable energy source. This work aims to analyze the pyrolysis kinetics of CHA for the production of biochar and show the potential of the biochar for electrochemical applications. The thermal degradation features of CHA were studied using thermogravimetric and TG-FTIR analysis. Meanwhile, Flynn-Wall-Ozawa and Kissinger-Akahira-Sunose methods were applied for the evaluation of kinetic parameters. CHA was then pyrolyzed using the microwave-assisted method to obtain biochar. The biochar structure and components were characterized by SEM, XRD, and Raman spectra. And the electrocatalytic performance was measured via cyclic voltammetry (CV) test with the biochar-modified electrode. It was found that the volatile products mainly contained water, methane, carboxylic acid, ketones, aldehyde groups, and NH 3 indicated by the real-time online FTIR spectra. And the comprehensive characterization showed that the CHA-derived biochar had unique properties as a superior functionalizing material for electrochemical applications. To sum up, we innovatively proposed to apply the biochar from the pyrolysis of CHA as an electrode functionalizing material and further evaluated the detection performance of the modified electrode.

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Lactate‐Oxidase‐Instructed Cancer Diagnosis and Therapy

et al. 2023

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Lactate oxidase (LOx) has attracted extensive interest in cancer diagnosis and therapy in recent years owing to its specific catalysis on l‐lactate; its catalytic process consumes oxygen (O2) and generates a large amount of hydrogen peroxide (H2O2) and pyruvate. Given high levels of lactate in tumor tissues and its tight correlation with tumor growth, metastasis, and recurrence, LOx‐based biosensors including H2O2‐based, O2‐based, pH‐sensitive, and electrochemical have been designed for cancer diagnosis, and various LOx‐based cancer therapy strategies including lactate‐depletion‐based metabolic cancer therapy/immunotherapy, hypoxia‐activated chemotherapy, H2O2‐based chemodynamic therapy, and multimodal synergistic cancer therapy have also been developed. In this review, the lactate‐specific catalytic properties of LOx are introduced, and the recent advances on LOx‐instructed cancer diagnostic or therapeutic platforms and corresponding biological applications are summarized. Additionally, the challenges and potential of LOx‐based nanomedicines are highlighted.

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Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for real-time detection of lactic acid from cancer cell metabolism

Cited by 39 publications

References 47 publications

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

From green tide to biochar: Thermal decomposition kinetics and TG‐FTIR study of microalgae from Chaohu Lake

Lactate‐Oxidase‐Instructed Cancer Diagnosis and Therapy

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