Porous Cellulose Beads Fabricated from Regenerated Cellulose as Potential Drug Delivery Carriers

Voon, Lee Ken; Pang, Suh Cem; Chin, Suk Fun

doi:10.1155/2017/1943432

Cited by 31 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1-allyl-3-methylimidazolium chloride, an ionic liquid was used as solvent to prepare cellulose particles from cellulose paper wastes [173]. Using a syringe, the cellulose solution was dropped into a water coagulation medium.…”

Section: State Of the Art Of Bio-aerogel Particlesmentioning

confidence: 99%

Review on the Production of Polysaccharide Aerogel Particles

et al. 2018

View full text Add to dashboard Cite

A detailed study of the production of polysaccharide aerogel (bio-aerogel) particles from lab to pilot scale is surveyed in this article. An introduction to various droplets techniques available in the market is given and compared with the lab scale production of droplets using pipettes and syringes. An overview of the mechanisms of gelation of polysaccharide solutions together with non-solvent induced phase separation option is then discussed in the view of making wet particles. The main steps of particle recovery and solvent exchange are briefly described in order to pass through the final drying process. Various drying processes are overviewed and the importance of supercritical drying is highlighted. In addition, we present the characterization techniques to analyse the morphology and properties of the aerogels. The case studies of bio-aerogel (agar, alginate, cellulose, chitin, κ-carrageenan, pectin and starch) particles are reviewed. Potential applications of polysaccharide aerogel particles are briefly given. Finally, the conclusions summarize the prospects of the potential scale-up methods for producing bio-aerogel particles.

show abstract

Section: State Of the Art Of Bio-aerogel Particlesmentioning

confidence: 99%

Review on the Production of Polysaccharide Aerogel Particles

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Cellulose beads (CBs) are smaller-sized particles prepared through the usual route of dissolution of cellulose or cellulose derivatives followed by shaping into a spherical form, sol–gel transition, drying, and fine-tuning of pore characteristics [ 137 ]. Particularly, shaping is the most crucial step in CBs preparation, which is usually achieved either by dispersion techniques or dropping the cellulose solution into a coagulating bath using droplet forming machines such as atomizers and jet cutting machines [ 138 ]. In the dropping technique, beads are formed by the solidification of cellulose solution by adding it drop-wise into an aqueous coagulating medium ( Figure 6 ).…”

Section: Surface Modification Of Cellulose and Cellulose Bioproductsmentioning

confidence: 99%

Production and Surface Modification of Cellulose Bioproducts

Liyanage¹,

Acharya²,

Parajuli³

et al. 2021

Polymers

View full text Add to dashboard Cite

Petroleum-based synthetic plastics play an important role in our life. As the detrimental health and environmental effects of synthetic plastics continue to increase, the renewable, degradable and recyclable properties of cellulose make subsequent products the “preferred environmentally friendly” alternatives, with a small carbon footprint. Despite the fact that the bioplastic industry is growing rapidly with many innovative discoveries, cellulose-based bioproducts in their natural state face challenges in replacing synthetic plastics. These challenges include scalability issues, high cost of production, and most importantly, limited functionality of cellulosic materials. However, in order for cellulosic materials to be able to compete with synthetic plastics, they must possess properties adequate for the end use and meet performance expectations. In this regard, surface modification of pre-made cellulosic materials preserves the chemical profile of cellulose, its mechanical properties, and biodegradability, while diversifying its possible applications. The review covers numerous techniques for surface functionalization of materials prepared from cellulose such as plasma treatment, surface grafting (including RDRP methods), and chemical vapor and atomic layer deposition techniques. The review also highlights purposeful development of new cellulosic architectures and their utilization, with a specific focus on cellulosic hydrogels, aerogels, beads, membranes, and nanomaterials. The judicious choice of material architecture combined with a specific surface functionalization method will allow us to take full advantage of the polymer’s biocompatibility and biodegradability and improve existing and target novel applications of cellulose, such as proteins and antibodies immobilization, enantiomers separation, and composites preparation.

show abstract

“…Curcumin release study was conducted based on the methodology reported by Voon et al 7,19 About 50 mg of curcumin loaded amino-starch nanoparticles were dispersed in 15 ml of phosphate-buffered saline (PBS) at two different pH values:…”

Section: Curcumin Release Studymentioning

confidence: 99%

Amino-starch Nanoparticles as Controlled Release Nanocarriers for Curcumin

Kemin¹,

Chin²

2020

JPS

View full text Add to dashboard Cite

Curcumin is a naturally occurring phytochemical with interesting therapeutical properties. However, it shows some limitations of low intrinsic solubility, fast degradation and poor bioavailability. In this study, curcumin was loaded onto aminofunctionalised starch (amino-starch) nanoparticles via the nanoprecipitation method in an attempt to increase its water solubility. In this nanoprecipitation process, the aminostarch aqueous solution was added into excess ethanolic solution under stirring. Aminostarch nanoparticles were formed as organic solvent got separated from the amino-starch. Amino-starch nanoparticles with mean particle size of 163 nm were obtained by dropwise addition of dissolved amino-starch solution into excess absolute ethanol solution containing curcumin. Amino-starch nanoparticles showed enhanced curcumin loading capacity of 0.76 mg mg -1 as compared to 0.33 mg mg -1 for native starch nanoparticles. Curcumin was observed to release out slowly from amino-starch nanoparticles over a period of 12 h. Therefore, the potential of amino-starch nanoparticles as the controlled release nanocarriers for curcumin was demonstrated.

show abstract

Porous Cellulose Beads Fabricated from Regenerated Cellulose as Potential Drug Delivery Carriers

Cited by 31 publications

References 26 publications

Review on the Production of Polysaccharide Aerogel Particles

Review on the Production of Polysaccharide Aerogel Particles

Production and Surface Modification of Cellulose Bioproducts

Amino-starch Nanoparticles as Controlled Release Nanocarriers for Curcumin

Contact Info

Product

Resources

About