Porous Electrospun Fibers with Self‐Sealing Functionality: An Enabling Strategy for Trapping Biomacromolecules

Jin, Zhang; Zheng, Ting; Alarçin, Emine; Byambaa, Batzaya; Guan, Xiaofei; Ding, Jianxun; Zhang, Yu Shrike; Li, Zhong‐Ming

doi:10.1002/smll.201701949

Cited by 41 publications

(32 citation statements)

References 87 publications

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“…By this means, numerous ISF biomarkers could be extracted, accumulated, and analyzed accurately in vitro . However, as most existing MNs could only absorb ISF, they must employ other extra methods, including biosensors, electrodes, and ELISA, to distinguish the biomarkers and achieve the specific detection, which complicate the detection procedure and make it difficult to realize multiplex detection. This together with their intricate and inflexible fabrications, which usually require some sophisticated technology such as photolithography, laser ablation, and etching, has limited their clinical applications.…”

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confidence: 99%

Encoded Microneedle Arrays for Detection of Skin Interstitial Fluid Biomarkers

et al. 2019

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Skin interstitial fluid (ISF) is considered as an emerging source of biomarkers with physiological and medical significance. Microneedle arrays (MNs) provide a promising means for painless, noninvasive detection of these biomarkers. Here, novel MNs integrated with photonic crystal (PhC) barcodes are presented, and multiplex specific detection of ISF biomarkers is realized for the first time. The PhC barcodes‐loaded flexible MNs are simply fabricated by replicating dynamic ferrofluid‐cast micromoldings. When the prepared MNs are inserted into skin, they can enrich specific biomarkers to their probes‐decorated PhC barcodes. Thus, by adding corresponding fluorescent probes to form sandwich immunocomplexes, the relative content of the biomarkers can be read out through the fluorescence intensity of the barcodes; meanwhile, the species of these biomarkers can be clearly distinguished by the reflection peaks of the PhC barcodes. Based on the encoded MNs, their sensitivity, flexibility, and versatility of capturing and detecting three inflammatory cytokines are demonstrated in a sepsis mice model. Compared with existing MNs for ISF detection, the encoded MNs not only possess equivalent detection effects with less post‐processing and simplified procedures, but can also detect multiple biomarkers simultaneously, which makes them ideal in many clinical and biomedical detection areas.

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confidence: 99%

Encoded Microneedle Arrays for Detection of Skin Interstitial Fluid Biomarkers

et al. 2019

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“…Incorporation of PEO in electrospun fibers or co‐electrospinning PEO fibers with other polymers has been used successfully to increase pore size and improve cell infiltration . PEO leaching from electrospun fibers may also be used as a strategy to create nanopores at the fiber's surface and increase scaffold's porosity …”

Section: Resultsmentioning

confidence: 99%

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Valente

Ferreira

Henriques

et al. 2018

J of Applied Polymer Sci

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Nonwoven membranes of poly(ε‐caprolactone) (PCL) and chitosan (CS) were produced according to the two methods: by blending the polymers in solution followed by electrospinning – polymer blending method – and by simultaneous deposition of fibers electrospun from separate solutions – fiber blending (FB) method. The two production methods were compared by assessing fiber morphology, mass loss, swelling degree, water contact angle, and mechanical properties of the resulting electrospun membranes. Furthermore, the adhesion, proliferation, and morphology of human dermal fibroblasts on the eight types of scaffold produced were evaluated to assess if the blending method used would influence cell–scaffold interaction. Cell adhesion to the different scaffolds lied in the interval 40–60%, with the CS scaffold presenting the lowest value. Interestingly, cell proliferation was the same when comparing polymer blending and FB scaffolds having 3:1 or 1:3 PCL/CS ratios but very different when the ratio was 1:1 – the FB scaffold sustained a proliferation rate double that of the polymer blending scaffold. This work shows that, when blending polymers to improve the properties of a scaffold for tissue engineering or 3D cell culture, their spatial distribution may considerably affect scaffold's properties and should be considered as another parameter requiring optimization. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47191.

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“…Many medical devices made with these synthetic polymers have approved for clinical use in humans. As compared with other polymers, PLGA is much more versatile with regard to the control over degradation rate where poly(glycolic acid) is a highly crystalline polymer with a relatively fast degradation rate (Zhang et al, ). PLGA and poly(lactic acid) have similar structures; however, they have different types of properties.…”

Section: Osteobiologic Materialsmentioning

confidence: 99%

Advances in osteobiologic materials for bone substitutes

Hasan

Byambaa

Morshed

et al. 2018

J Tissue Eng Regen Med

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109

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A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts, and xenografts and thereby serve as implant materials as bone substitutes for bone repair or remodelling. The complex biology behind the nanostructure and microstructure of bones and their repair mechanisms, which involve various types of chemical and biomechanical signalling amongst different cells, has set strong requirements for biomaterials to be used in bone tissue engineering. This review presents an overview of various types of osteobiologic materials to facilitate the formation of the functional bone tissue and healing of the bone, covering metallic, ceramic, polymeric, and cell-based graft substitutes, as well as some biomolecular strategies including stem cells, extracellular matrices, growth factors, and gene therapies. Advantages and disadvantages of each type, particularly from the perspective of osteoinductive and osteoconductive capabilities, are discussed. Although the numerous challenges of bone regeneration in tissue engineering and regenerative medicine are yet to be entirely addressed, further advancements in osteobiologic materials will pave the way towards engineering fully functional bone replacement grafts.

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Porous Electrospun Fibers with Self‐Sealing Functionality: An Enabling Strategy for Trapping Biomacromolecules

Cited by 41 publications

References 87 publications

Encoded Microneedle Arrays for Detection of Skin Interstitial Fluid Biomarkers

Encoded Microneedle Arrays for Detection of Skin Interstitial Fluid Biomarkers

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Advances in osteobiologic materials for bone substitutes

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