Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

Elbadawi, Moe; Wally, Zena J.; Reaney, Ian M.

doi:10.1111/jace.15514

Cited by 15 publications

(10 citation statements)

References 77 publications

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“…In addition, increasing the BG phase from 30 to 50 wt.% reduces the density, compared to pure HAp. Therefore, the HAp/BG with 50 wt.% was dissolved in SBF solution [43].…”

Section: Effect Of Hap/bg Ratio On Compressive Strength Of Hap and Hap/bg Cementmentioning

confidence: 99%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) have been applied as appropriate materials for bone tissue engineering. In this study, hydroxyapatite/bioglass cement in different ratios was successfully fabricated. To prepare HAp and HAp/BG cement, synthesized HAp and HAp/BG powder were mixed in several ratios, using different concentrations of sodium hydrogen phosphate (SP) and water as the liquid phase. The liquid to powder ratio used was 0.4 mL/g. The results showed that setting time increased with BG content in the composite. The results also showed that with the addition of bioglass to the HAp structure, the density decreased and the porosity increased. It was also found that after immersion in simulated body fluid (SBF) solution, the compressive strength of the HAp and HAp/BG cements increased with BG concentration up to 30 wt.%. SEM results showed the formation of an apatite layer in all selected samples after immersion in SBF solution. At 30 wt.% BG, greater nucleation and growth of the apatite layer were observed, resulting in higher bioactivity than pure HAp and HAp/BG in other ratios.

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“…In addition, increasing the BG phase from 30 to 50 wt.% reduces the density, compared to pure HAp. Therefore, the HAp/BG with 50 wt.% was dissolved in SBF solution [43].…”

Section: Effect Of Hap/bg Ratio On Compressive Strength Of Hap and Hap/bg Cementmentioning

confidence: 99%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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“…1,2 Hydroxyapatite (HA), one of the main components of bone tissue, has recently been paid increased attention in bone repair and other medical fields. 3,4 Researchers generally believe that the nutrient transfer required for cell growth and adhesion in bone stents requires intermediate connecting channels (50−1000 μm). [5][6][7] Therefore, ensuring the high accuracy of bracket manufacturing is an important consideration in bone scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Study of falling‐down‐type DLP 3D printing technology for high‐resolution hydroxyapatite scaffolds

You

et al. 2021

Int J Applied Ceramic Tech

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In this study, a strategy to print hydroxyapatite (HA) ceramics based on fallingdown-type digital light processing (DLP) 3D printing technology with high accuracy was proposed. The monolayer curing thickness and curing broadening of the samples were compared under different conditions, and the most suitable photoinitiator for the system and optimal amount of additive dye in the slurry were obtained. The light power density and single-layer exposure time of the light source of the DLP printer were optimized, and a number of high-resolution models of HA scaffolds with an exact square-channel aperture width of 380 μm were successfully printed. The shrinkage, microstructural, and mechanical properties of the HA ceramic scaffolds were studied at different sintering temperatures. The microstructure and composition of the scaffolds were also characterized by scanning electron microscopy and X-ray diffractometry. The compressive strength and compressive modulus of HA porous scaffold were 11.61 MPa and 1.26 GPa, respectively. And the porosity of scaffold was 31.67%.

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“…The honeycomb scaffolds have a periodic porous architecture with parallel channel-like macropores, identical macropore size, and unidirectional interconnectivity, which are responsible for their high mechanical strength . The macropore size and shape can be adjusted by changing the extrusion die geometry . However, as bone grafts, the honeycomb bioceramic scaffolds are short of 3D pore interconnectivity.…”

Section: Introductionmentioning

confidence: 99%

Novel Extrusion-Microdrilling Approach to Fabricate Calcium Phosphate-Based Bioceramic Scaffolds Enabling Fast Bone Regeneration

Fang

et al. 2020

ACS Appl. Mater. Interfaces

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This study proposes a novel approach, termed extrusion-microdrilling, to fabricate three-dimensional (3D) interconnected bioceramic scaffolds with channel-like macropores for bone regeneration. The extrusion-microdrilling method is characterized by ease of use, high efficiency, structural flexibility, and precision. The 3D interconnected β-tricalcium phosphate bioceramic (EM-TCP) scaffolds prepared by this method showed channel-like square macropores (∼650 μm) by extrusion and channel-like round macropores (∼570 μm) by microdrilling as well as copious micropores. By incorporating a strontium-containing phosphate-based glass (SrPG), the obtained calcium phosphate-based bioceramic (EM-TCP/SrPG) scaffolds had noticeably higher compressive strength, lower porosity, and smaller macropore size, tremendously enhanced in vitro proliferation and osteogenic differentiation of mouse bone marrow stromal cells, and suppressed in vitro osteoclastic activities of RAW264.7 cells, as compared with the EM-TCP scaffolds. In vivo assessment results indicated that at postoperative week 6, new vessels and a large percentage of new bone tissues (24–25%) were formed throughout the interconnected macropores of EM-TCP and EM-TCP/SrPG, which were implanted in the femoral defects of rabbits; the bone formation of the EM-TCP group was comparable to that of the EM-TCP/SrPG group. At 12 weeks postimplantation, the bone formation percentage of EM-TCP was slightly reduced, while that of EM-TCP/SrPG with a slower degradation rate was pronouncedly increased. This work provides a new strategy to fabricate interconnected bioceramic scaffolds allowing for fast bone regeneration, and the EM-TCP/SrPG scaffolds are promising for efficiently repairing bone defects.

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Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

Cited by 15 publications

References 77 publications

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Study of falling‐down‐type DLP 3D printing technology for high‐resolution hydroxyapatite scaffolds

Novel Extrusion-Microdrilling Approach to Fabricate Calcium Phosphate-Based Bioceramic Scaffolds Enabling Fast Bone Regeneration

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