Porous Hydroxyapatite Bioceramic Scaffolds for Drug Delivery and Bone Regeneration

Loča, Dagnija; Ločs, Jānis; Salma, Kristine; Gulbis, Juris; Šalma, Ilze; Bērziņa-Cimdiņa, Līga

doi:10.1088/1757-899x/18/19/192019

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…The latter describes that with increasing PF concentration less area is available for the gas to develop inside the polymer matrix, which results in a smaller average size of the gas bubbles. Interestingly, the observed pore sizes are in accordance with those reported both for PU scaffolds produced via different manufacturing methods such as salt leeching (250 µm [ 64 ]) and gas foaming (60–300 µm [ 100 ]) and for systems produced via HME but using Eudragit ® as the polymer matrix (200 µm [ 101 ]).…”

Section: Resultssupporting

confidence: 85%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

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Section: Resultssupporting

confidence: 85%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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“…The in vitro drug release were carried out on the drug loaded discs for both porous n-HAp and porous n-HAp/MWCNTs after subjecting them to a freeze drying (liophilization).And then such discs were immersed in amber glass vials containing a freshly prepared phosphate buffer solution with pH(6.8) and then placed in a shaker water bath with an adjusted temperature at 37ᴼC at different time intervals (1,2,3,4,6,8,24,48,69,144,192 hrs.) 2ml drug samples were withdrawn from such examined samples and immediately replaced with 2ml of donor phosphate buffer solution (pH 6.8) at each time intervals and for 8 days, in order to estimate the concentration and rate of drug release from drug loaded examined pellets at those particular time periods using UV-visible spectrophotometer at 271nm.…”

Section: Follow-up Of the Ciprofloxacin Releasementioning

confidence: 99%

“…In addition, high doses of drugs are necessary to get the desired effect. The use of local drug delivery as rout of administrations is An alternative approach able to release drug in a controlled way [1]. Therefore, the advantages of local antibiotic administration; high local levels with low systemic toxicity are nowadays recognized.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin

Albahy¹,

Abbas

Hezma

et al. 2020

J.Text.color. pol. sci.

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T HE MAIN objective of this study was synthesis a composite of porous n-HAp/MWCNTs loaded with ciprofloxacin (CFX) as a local drug delivery during surgical procedures with sustained release behavior in the treatment of bone infection minimizing the risks of systemic toxicity. Ciprofloxacin is used as an antibacterial of the Gram-positive and Gramnegative bacteria that affect the bones. The prepared scaffolds loaded with ciprofloxacin were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, Scanning Electron Microscope (SEM) and Cytotoxicity Testing. The in-vitro release of the drug of such scaffolds was also investigated as well as the study of the Entrapment efficiency of scaffold by using U.V spectroscopy. The cytotoxicity of hydroxyapatite containing MWCNTS applied on normal bone cells for the highest rate of 3 x 10 -3 showed the cell viability greater than 90%. The CFX was successfully loaded within such HAp-nano Scaffolds referred to their reasonable encapsulation efficiencies which they revealed. The drug release behavior showed promising sustained prolonged profiles up to 8 days with minimum initial burst effects.

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“…Materials used for drug delivery systems, span across various classes of biocompatible materials, including polymers such as synthetic polyorthoesters, poloaxmers, polyphosphazenes and natural polymers such as alginates and chitosan [19]. Other materials include inorganic materials such as hydroxyapatite and silica dioxide [20,21].…”

Section: Chapter 2 Literature Review 21 Drug Delivery Systemsmentioning

confidence: 99%

Core-shell structure alginate-PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

Lim¹

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for the help given. I would also like to give thanks and credit to my FYP students, Sherwyn Tan, Dickson Tjipto, Kara Cooper, He Xinyan and Leong Wei Wei for their time spent on this project with the hard work they had put in to understand this work in depth further. Special thanks is given to Dr Effendi Wijaja from Institute of Chemical & Engineering Sciences (A*STAR), for his expertise help with the BTEM / Raman mapping to elucidate the core-shell particulate morphology. Also, my gratitude for the generosity of A/P Phan Anh Tuan, Chung Wan Jun; and Prof Richard Webster from the School of Physical and Mathematical Sciences (NTU) for the use of the Jasco CD spectropolarimeter and the Nicolet Continµum FT-IR microscope. Also, all electron microscopy and X-ray microanalysis performed in this work was conducted in NTU Facility for Analysis, Characterisation, Testing and Simulation (FACTS) laboratory.

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Porous Hydroxyapatite Bioceramic Scaffolds for Drug Delivery and Bone Regeneration

Cited by 15 publications

References 11 publications

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin

Core-shell structure alginate-PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs

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