Porous hydroxyapatite for artificial bone applications

Sopyan, Iis; Mel, Maizirwan; Ramesh, S.; Khalid, Kamarul Ariffin

doi:10.1016/j.stam.2006.11.017

Cited by 364 publications

(210 citation statements)

References 56 publications

(64 reference statements)

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“…The implemented model using CAD can be manufactured with the development of the solid freeform fabrication (SFF) technology. And then, the porous synthetic bone scaffolds can be fabricated using the polymer mold fabricated by SFF (7)(8)(9). Eventually, the HA scaffold, fabricated by SFF has the advantage of easy control of pore size.…”

mentioning

confidence: 99%

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Kwon

Kim²,

Kim³

et al. 2013

Artificial Organs

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Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested threedimensional model has interconnected cubic pores of 500 mm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.

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mentioning

confidence: 99%

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Kwon

Kim²,

Kim³

et al. 2013

Artificial Organs

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“…In addition, these connections between pores allow blood circulation, the exchange of body fluids and the diffusion of ions. Unconnected pores do not participate in these physiological events that are necessary for regeneration 36 . In the present study, QN scaffold has pores of around 52.5 ± 3.2 µm.…”

Section: Macroscopic and Radiological Analysismentioning

confidence: 99%

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

et al. 2017

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Biomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate these materials in the repair of cranial defects in rats. The animals were divided in groups: without implant (G1), implanted with the chitosan/carbon nanotube membrane (G2), and chitosan/nanotube membrane mineralized with hydroxyapatite (G3). The animals were sacrificed 5 weeks after surgery and the skulls were removed for analysis of the defect area. The results showed absence of chronic inflammatory and little bone neoformation in the defect area of all groups. In G2 and G3 there was lack of reabsorption of the biomaterial that were encapsulated by connective tissue. In conclusion, the biomaterials were biocompatible, but their specific physicochemical properties did not indicate a considerable osteoregenerative capacity.

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“…A number of factors affect the feedstock properties, such as the speed and mixing time, geometry of the mixing blades, temperature, particle characteristics, composition, and viscosity [5,6]. Hydroxyapatite (HA) and titanium are key elements in the development of medical components [7]. HA or [Ca10(PO4)6(OH)2] is a calcium phosphate ceramics currently used as a bioactive material for dental and orthopedic applications [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of mixing parameters on the mixing time and density of composite HA/Ti6Al4V feedstock for powder injection molding

Arifin

Sulong

2017

MATEC Web Conf.

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Abstract. Hydroxyapatite is a bioactive material. However, Hydroxyapatite in medical application is limited by its poor mechanical properties. Titanium alloys are biocompatible materials with high specific strength and high corrosion resistance. This combination can successfully be used in biomedical applications. The mixing process is a critical stage in the metal injection molding process because it determines the quality of the metal injection product. The homogeneity of the feedstock depends on the mixing parameters used during the mixing process. An experiment was conducted using Ti6Al4V and hydroxyapatite powder as feedstock at a mixing ratio of 60:40 wt%. This feedstock was mixed with a mixture of polyethylene and palm stearin as the binder. The mixing parameters used in this study were the mixing speed (10 and 30 rpm) and the mixing temperature (130°C and 150°C) at a powder loading of 67%, as determined by the critical powder volume percentage experiment data (69.5%). Increases in the mixing speed and mixing temperature reduced the mixing time to achieve homogeneity. The combined feedstock achieved the highest density at a mixing speed of 30 rpm and a mixing temperature of 150°C.

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Porous hydroxyapatite for artificial bone applications

Cited by 364 publications

References 56 publications

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

Effect of mixing parameters on the mixing time and density of composite HA/Ti6Al4V feedstock for powder injection molding

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