Porous microneedle-based wearable device for monitoring of transepidermal potential

Abe, Yuina; Takizawa, Ryohei; Kimura, Naruhiro; Konno, Hajime; Yoshida, Shizuo; Nishizawa, Masatoyo

doi:10.1016/j.bea.2021.100004

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…7(d) ]. 234 As mentioned above, electrical stimulation may promote barrier recovery, 127,193 suggesting the possibility of a multifunctional device that performs both evaluation and control of the epidermal barrier. Further elucidation of the mechanism and validation of the effects of the device will be required to develop a device that can be applied to treat chronic skin abnormalities associated with reduced barrier function.…”

Section: Skin Devices Based On the Electrical Features Of The Skinmentioning

confidence: 99%

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Electrical aspects of skin as a pathway to engineering skin devices

Abe

Nishizawa

2021

APL Bioengineering

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Skin is one of the indispensable organs for life. The epidermis at the outermost surface provides a permeability barrier to infectious agents, chemicals, and excessive loss of water, while the dermis and subcutaneous tissue mechanically support the structure of the skin and appendages, including hairs and secretory glands. The integrity of the integumentary system is a key for general health, and many techniques have been developed to measure and control this protective function. In contrast, the effective skin barrier is the major obstacle for transdermal delivery and detection. Changes in the electrical properties of skin, such as impedance and ionic activity, is a practical indicator that reflects the structures and functions of the skin. For example, the impedance that reflects the hydration of the skin is measured for quantitative assessment in skincare, and the current generated across a wound is used for the evaluation and control of wound healing. Furthermore, the electrically charged structure of the skin enables transdermal drug delivery and chemical extraction. This paper provides an overview of the electrical aspects of the skin and summarizes current advances in the development of devices based on these features.

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Section: Skin Devices Based On the Electrical Features Of The Skinmentioning

confidence: 99%

Section: Skin Devices Based On the Electrical Features Of The Skinmentioning

confidence: 99%

Electrical aspects of skin as a pathway to engineering skin devices

Abe

Nishizawa

2021

APL Bioengineering

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“…The figure is drawn based on the explanation found in various studies. [ 27,41,118,129,130,132–135 ]…”

Section: Microarray Patch and Its Application To Collect Biomarkers C...mentioning

confidence: 99%

“…[ 27,134 ] Human tissue electrical potential, which is one of the indicators of a physiological process, can also be directly measured using this type of integrated gadget. [ 135 ] Usually, surface functionalization or enzymatic reactions are required to provide better selectivity and sensitivity to the detection process. [ 130,134 ] Enzymatic‐based detection devices are beneficial for continuous monitoring because the analytes are consumed upon reaction, thus providing the imbalance needed for molecular diffusion of extracellular fluid, assuming the microneedle array acts as a continuous channel that links the liquid in the sensing compartment and the tissue underneath.…”

Section: Microarray Patch and Its Application To Collect Biomarkers C...mentioning

confidence: 99%

“…The figure is drawn based on the explanation found in various studies. [27,41,118,129,130,[132][133][134][135] for CLE and SLE may facilitate earlier diagnosis, accurate clinical management, and identification of the personal risk for individual patients as the disease develops. [211,213,217]…”

Section: Systemic Lupus Erythematosus (Sle) and Cutaneous Lupus Eryth...mentioning

confidence: 99%

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Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Himawan

Vora

Permana

et al. 2022

Adv Healthcare Materials

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Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from the fluids surrounding the diseased tissues may give more important clinical value than measuring them at a systemic level. Despite all these facts, pushing tissue fluid-based diagnosis and monitoring forward to clinical settings faces one major problem: its accessibility. Most extracellular tissue fluid, such as interstitial fluid (ISF), is abundant but hard to collect, and the currently available technologies are invasive and expensive. This is where novel microneedle technology can help tackle this significant obstacle. The ability of microneedle technology to minimally invasively access tissue fluid-containing biomarkers will enable ISF and other tissue fluid utilization in the clinical diagnosis and monitoring of localized diseases. This review attempts to present the current pursuit of the application of microneedle systems as a diagnostic and monitoring platform, along with the recent progress of biomarker detection in diagnosing and monitoring localized external organ diseases. Then, the potential use of various microneedles in future clinical diagnostics and monitoring of localized diseases is discussed by presenting the currently studied cases.

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Engineering the Functional Expansion of Microneedles

Yang,

Xu,

Zhu

et al. 2024

Advanced Materials

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Microneedles (MNs), composed of an array of micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic needles in drug delivery and fluid collection, advancing toward multifunctional platforms. In this review, four major areas are summarized in interdisciplinary engineering approaches combined with MNs technology. First, electronics engineering, the most extensively researched field, enables applications in biomonitoring, electrical stimulation, and closed‐loop theranostics through the generation, transmission, and transformation of electrical signals. Second, in electromagnetic engineering, the responsiveness of electromagnetic induction offers prospects for remote and programmable therapeutic applications. Third, photonic engineering endows MNs with novel functionalities, such as waveguiding and photonic manipulation to enhance optical therapeutic capabilities and facilitate the visualization of disease progression and treatment processes. Lastly, it reviewed the role of mechanical engineering in conferring shape adaptability and programmable motion features necessary for various MNs applications. This review focuses on the functionalities that emerge from the intersection of MNs with complementary engineering technologies, aiming to inspire further research and innovation in microneedle technology for biomedical applications.

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Porous microneedle-based wearable device for monitoring of transepidermal potential

Cited by 13 publications

References 36 publications

Electrical aspects of skin as a pathway to engineering skin devices

Electrical aspects of skin as a pathway to engineering skin devices

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Engineering the Functional Expansion of Microneedles

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