Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc‐Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair

Abstract

Hydroxyapatite nanowires exhibit a great potential in biomedical applications owing to their high specific surface area, high flexibility, excellent mechanical properties, and similarity to mineralized collagen fibrils of natural bone. In this work, zinc-containing nanoparticle-decorated ultralong hydroxyapatite nanowires (Zn-UHANWs) with a hierarchical nanostructure have been synthesized by a one-step solvothermal method. The highly flexible Zn-UHANWs exhibit a hierarchical rough surface and enhanced specific surface area as compared with ultralong hydroxyapatite nanowires (UHANWs). To evaluate the potential application of Zn-UHANWs in bone regeneration, the biomimetic Zn-UHANWs/chitosan (CS) (Zn-UHANWs/CS) composite porous scaffold with 80 wt % Zn-UHANWs was prepared by incorporating Zn-UHANWs into the chitosan matrix by the freeze-drying process. The as-prepared Zn-UHANWs/CS composite porous scaffold exhibits enhanced mechanical properties, highly porous structure, and excellent water retention capacity. In addition, the Zn-UHANWs/CS porous scaffold has a good biodegradability with the sustainable release of Zn, Ca, and P elements in aqueous solution. More importantly, the Zn-UHANWs/CS porous scaffold can promote the osteogenic differentiation of rat bone marrow derived mesenchymal stem cells and facilitate in vivo bone regeneration as compared with the pure CS porous scaffold or UHANWs/CS porous scaffold. Thus, both the Zn-UHANWs and Zn-UHANWs/CS porous scaffold developed in this work are promising for application in bone defect repair.

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

“…All above results indicated that Zn element was indeed embedded into the titanium substrate. Many studies have found the Zn element is essential for a variety of biological systems, including bone metabolism and dental development [29, 30]. Recent research has also considered it as an antioxidant to defend organism away from reactive oxygens [31].…”

Induced Osteogenesis in Plants Decellularized Scaffolds

“…However, a donor organ is required for this purpose; and with respect to bone, autologous grafts (the best option for seeding) are not only limited in supply but also impose donor site problems. Instead, scaffolds are being fabricated from or coated with major components of bone ECM, such as HA or type I collagen, to generate bone-like tissue in vitro 21–23 . Furthermore, 3D bioprinting with cell-loaded bioink is emerging as another attractive option 24 , albeit rooted in high-tech devices.…”

Fire‐Retardant and High‐Temperature‐Resistant Label Paper and Its Potential Applications

“…Through continuous efforts and attempts, this research team has successfully developed many kinds of fire-resistant paper with different functions and uses using ultralong HAP nanowires as the main building material. [14][15][16][17][18][19][20][21][22][23][24][25][26][27] For example, the flexible fireproof inorganic nanocomposite paper as the protection layer in flame-retardant optical fiber cable, [25] fire-resistant inorganic analogous Xuan Paper with thousands of years' super-durability, [26] and highperformance filter paper for water purification. [27] In this work, a new kind of fire-retardant and high-temperature-resistant hydroxyapatite (HAP) nanowire/aramid label paper has been developed, the effects of the content of HAP nanowires on the mechanical strength, high-temperature resistance and flame-retardant performance of the as-prepared HAP nanowire/aramid label paper are investigated.…”

“…The high aspect ratio and hydroxyl groups of ultralong HAP nanowires make them interweave with each other and form hydrogen bonds, which is benefical for enhancing the mechanical properties of the fire‐resistant paper. Through continuous efforts and attempts, this research team has successfully developed many kinds of fire‐resistant paper with different functions and uses using ultralong HAP nanowires as the main building material . For example, the flexible fireproof inorganic nanocomposite paper as the protection layer in flame‐retardant optical fiber cable, fire‐resistant inorganic analogous Xuan Paper with thousands of years’ super‐durability, and high‐performance filter paper for water purification …”