Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency

Liu, Yamin; Wang, Ze-Kun; Gao, Zhong‐Zheng; Zong, Yongqiang; Sun, Jian-Da; Zhou, Wei; Wang, Hui; Ma, Da; Li, Zhan‐Ting; Zhang, Dan‐Wei

doi:10.1016/j.actbio.2022.07.043

Cited by 10 publications

(3 citation statements)

References 46 publications

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“…However, EPR theory suffers from controversy evidenced by a new exploration result. , There are abundant types of nanocarriers serving as the scaffolds to deliver porphyrins in vivo , which are comprised of porous nanocarriers (silica, carbon, polydopamine, metal organic framework (MOF), covalent organic framework (COF), etc. ), nanoparticles formed by the self-assembly of amphiphiles (lipids and amphiphilic copolymers), and others. , However, both encapsulation and surface absorption of the nanocarriers can result in diffusion erosion of porphyrins from nanocarriers into medium during long-term medicament storage and in vivo circulation. Although shells (lipids, SiO 2 , etc.…”

Section: Introductionmentioning

confidence: 99%

“…), nanoparticles formed by the selfassembly of amphiphiles (lipids 57 and amphiphilic copolymers 58 ), and others. 59,60 However, both encapsulation and surface absorption of the nanocarriers can result in diffusion erosion of porphyrins from nanocarriers into medium during long-term medicament storage and in vivo circulation. Although shells (lipids, SiO 2 , etc.)…”

Section: Introductionmentioning

confidence: 99%

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Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Han,

Liu,

Peng

et al. 2023

Bioconjugate Chem.

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Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions in vivo, but not limited to these. In this article, we introduce the research progress of PBAs, including their constitution, structure design strategies, and performances in tumor and inflammation lesion diagnosis and treatments. On that basis, the defects of synthesized PBAs during their application and the possible effective strategies to overcome the limitations are also proposed. Finally, perspectives on PBAs exploration are updated based on our knowledge. We hope this review will bring researchers from various domains insights about PBAs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Han,

Liu,

Peng

et al. 2023

Bioconjugate Chem.

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“…Although safety concerns during the PDT process have been largely addressed, the risk of having symptoms like erythema, blistering, and pigmentation remains after the therapy. 9–13 Thus, patients must avoid exposure to light for up to 5 weeks. 14 Meanwhile, most developed sonosensitizers are photosensitive, perhaps due to a transient emission of light during cavitation being, according to previous proposals, the primary trigger of SDT.…”

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confidence: 99%

Erbium oxide nanoplates as a sonosensitizer devoid of photosensitivity

et al. 2023

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Recent Progress in Thermally Activated Delayed Fluorescence Photosensitizers for Photodynamic Therapy

Li,

Lu,

2024

Chemistry A European J

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Photodynamic therapy (PDT) is a rapidly growing discipline that is expected to become an encouraging noninvasive therapeutic strategy for cancer treatment. In the PDT process, an efficient intersystem crossing (ISC) process for photosensitizers from the singlet excited state (S1) to the triplet excited state (T1) is critical for the formation of cytotoxic reactive oxygen species and improvement of PDT performance. Thermally activated delayed fluorescence (TADF) molecules featuring an extremely small singlet–triplet energy gap and an efficient ISC process represent an enormous breakthrough for the PDT process. Consequently, the development of advanced TADF photosensitizers has become increasingly crucial and pressing. The most recent developments in TADF photosensitizers aimed at enhancing PDT efficiency for bio‐applications are presented in this review. TADF photosensitizers with water dispersibility, targeting ability, activatable ability, and two‐photon excitation properties are highlighted. Furthermore, the future challenges and perspectives of TADF photosensitizers in PDT are proposed.

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Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency

Cited by 10 publications

References 46 publications

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Erbium oxide nanoplates as a sonosensitizer devoid of photosensitivity

Recent Progress in Thermally Activated Delayed Fluorescence Photosensitizers for Photodynamic Therapy

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