Porous poly( dl -lactic acid) matrix film with antimicrobial activities for wound dressing application

Characterization of Antimicrobial Agent Loaded Eudragit RS Solvent Exchange-Induced In Situ Forming Gels for Periodontitis Treatment

“…When phosphate buffer solution diffused into the test system, the transparent liquid was transformed into opaque to check the movement of water or water front (10,11). This simple strategy was employed to study the water influx in terms of water diffusion rate calculated from opaque distance as a function of time.…”

“…In situ forming gel systems are particularly attractive for the delivery of drugs into the periodontal pocket for periodontitis treatment (8)(9)(10)(11). This administration can be easily and rapidly carried out, without pain, by using the proper needle and syringe (8).…”

“…When this prepared solution is injected into an aqueous environment, the watermiscible organic solvent dissipates into the surrounding environment while water migrates into the polymer matrix, leading to the formation of solid-like or semisolid form at the injection site due to polymer precipitation, which is accompanied by a sustained release of the incorporated drug (9). Ethyl cellulose and bleached shellac have been recently prepared to modulate the antimicrobial drugs release from in situ forming gel systems with solvent exchange mechanism (10,11). Atridox® and Atrigel® are injectable biodegradable delivery systems containing doxycycline hyclate (DH) using the polymer poly(DL-lactide) (PLA) dissolved in NMP (12,13).…”

Poly(lactic acid) blends in biomedical applications

“…Liu et al[138] investigated the effect of blending ethylene vinyl acetate copolymer (EVA) with PLA to develop paclitaxel eluting stent coatings, where the rate and amount drug release can be modulated by varying the amount of PLA in the blend. Chitrattha et al[139] report PLA/PEG based porous matrix films for the delivery of Gentamicin sulphate (GS) or metronidazole for wound dressing application. Compared to films of neat PLA, PLA/PEG based films are more amorphous and exhibit enhanced porosity and pore size which, in turn, increase the rates of water vapor and oxygen transmission, degradation rate and total drug release.…”

Single Solvent‐Based Film Casting Method for the Production of Porous Polymer Films

“…PLA was used in this study as an example, however the process would also be applicable for other polymer types (such as polystyrene). PLA has been investigated either alone, as a copolymer or blended with other biopolymers in porous forms (e.g., membranes or scaffolds) for numerous biomedical applications including wound dressing, soft tissue repair and bone and cartilage grafting . In this study, PLA porous films with different pore sizes were produced and their cytocompatibility was assessed using MG63 cell line.…”