Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function

Liang, Ahui; Zhang, Min; Hong, Luo; Niu, Longxing; Feng, Yuehua; Li, Mingzhong

doi:10.3390/ma13020285

Cited by 19 publications

(13 citation statements)

References 41 publications

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“…Comparable results were noted after live/dead staining of bacteria, where the concentration that started with 10% of BCD showed a highly effective antibacterial effect. In turn, Liang et al [ 111 ] incorporated poly(hexamethylene biguanide) hydrochloride (PHMB) into silk fibroin (SF) sponges to enhance antibacterial function. Antibacterial activity tests of the modified materials were conducted against E. coli and S. aureus.…”

Section: Antimicrobial Biomaterialsmentioning

confidence: 99%

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Vivcharenko

Trzaskowska

Przekora

2023

IJMS

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Infections that occur during wound healing involve the most frequent complications in the field of wound care which not only inhibit the whole process but also lead to non-healing wound formation. The diversity of the skin microbiota and the wound microenvironment can favor the occurrence of skin infections, contributing to an increased level of morbidity and even mortality. As a consequence, immediate effective treatment is required to prevent such pathological conditions. Antimicrobial agents loaded into wound dressings have turned out to be a great option to reduce wound colonization and improve the healing process. In this review paper, the influence of bacterial infections on the wound-healing phases and promising modifications of dressing materials for accelerated healing of infected wounds are discussed. The review paper mainly focuses on the novel findings on the use of antibiotics, nanoparticles, cationic organic agents, and plant-derived natural compounds (essential oils and their components, polyphenols, and curcumin) to develop antimicrobial wound dressings. The review article was prepared on the basis of scientific contributions retrieved from the PubMed database (supported with Google Scholar searching) over the last 5 years.

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Section: Antimicrobial Biomaterialsmentioning

confidence: 99%

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Vivcharenko

Trzaskowska

Przekora

2023

IJMS

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“…13,19 It can be incorporated into a variety of types of wound dressings such as gauze, bandages, sponges, foams, and surgical sutures. [211][212][213][214][215][216] Notwithstanding, numerous studies are being conducted to develop more efficient, multifunctional, and user-friendly PHMB-based wound dressings. 211 Generally, wound dressings can be classified into two categories.…”

Section: Wound Dressingmentioning

confidence: 99%

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Wang,

Hu,

Chiou

et al. 2023

Polym. Chem.

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“…The SF solution is generally used to produce scaffolds [ 59 , 60 ], sponges [ 61 , 62 ], hydrogels [ 63 , 64 ], films [ 65 , 66 ], and electrospun mats [ 67 , 68 ], which have applications in skin wound healing ( Figure 1 a).…”

Section: Preparation Of Sf-based Dressingsmentioning

confidence: 99%

Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing

et al. 2022

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The skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. In this regard, silk fibroin, a protein derived from silk fibres that has excellent properties, is noteworthy. Silk fibroin is highly biocompatible and biodegradable. It can easily make various dressings, which can be loaded with additional substances to improve healing. Dressings based on silk fibroin have anti-inflammatory, pro-angiogenic properties and significantly accelerate skin wound healing, even compared to commercially available wound dressings. Animal studies confirm the beneficial influence of silk fibroin in wound healing. Clinical research focusing on fibroin dressings is also promising. These properties make silk fibroin a remarkable natural material for creating innovative, simple, and effective dressings for skin wound healing. In this review, we summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings.

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Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function

Cited by 19 publications

References 41 publications

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing

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