Porous polymer scaffolds surface‐modified with arginine‐glycine‐aspartic acid enhance bone cell attachment and differentiation <i>in vitro</i>

Hu, Yunhua; Winn, Shelley R.; Krajbich, Ian; Hollinger, Jeffrey O.

doi:10.1002/jbm.a.10438

Cited by 159 publications

(99 citation statements)

References 22 publications

(17 reference statements)

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“…The plasma treatment of PHB induced a durable conversion from a hydrophobic into a hydrophilic surface without significantly altering the morphology. Hollinger's group proposed a surface modification method using ammonia plasma treatment, followed by the attachment of poly(Llysine) and RGD peptide [116]. The surface-modified polymer films enhanced osteoprogenitor cell attachment.…”

Section: Surface Modificationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Section: Surface Modificationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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“…Several groups have successfully incorporated or coated RGD, or RGD-containing oligopeptides into synthetic materials and shown a modest improvement in osteoblast and osteoprogenitor cell functionality. 87,88,159 One explanation for the only modest improvement in cell adhesion, spreading, and mineralization is that the RGD peptide lacks integrin binding selectivity and triggers non-discriminatory cell attachment. Research is ongoing to discover more selective peptide sequences which trigger osteoblast adhesion.…”

Section: Chemical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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“…Several authors used low pressure plasma systems to activate PLGA scaffolds (O 2 /CO 2 , Ar and NH 3 plasma, respectively) fabricated via phase separation/ salt leaching in order to immobilize a biomacromolecule of choice [99][100][101]. Hu et al [101] immobilized both polylysine (enhances electrostatic interactions) and RGD peptides, using a glutaraldehyde linker.…”

Section: Non-thermal Plasmamentioning

confidence: 99%

“…Hu et al [101] immobilized both polylysine (enhances electrostatic interactions) and RGD peptides, using a glutaraldehyde linker. Osteogenic precursor cells were seeded onto the scaffolds and after 14 and 28 days, alkaline phosphatase (ALP) activity and calcium assays were performed to determine the level of osteogenic differentiation.…”

Section: Non-thermal Plasmamentioning

confidence: 99%

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

Mieno¹

2016

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Non-thermal plasma technology is one of those techniques that suffer relatively little from diffusion limits, slow kinetics, and complex geometries compared to more traditional liquid-based chemical surface modification techniques. Combined with a lack of solvents, preservation of the bulk properties, and fast treatment times; it is a well-liked technique for the treatment of materials for biomedical applications. In this book chapter, a review will be given on what the scientific community determined to be essential to obtain appropriate scaffolds for tissue engineering and how plasma scientists have used non-thermal plasma technology to accomplish this. A distinction will be made depending on the scaffold fabrication technique, as each technique has its own set of specific problems that need to be tackled. Fabrication techniques will include traditional fabrication methods, rapid prototyping, and electrospinning. As for the different plasma techniques, both plasma activation and grafting/polymerization will be included in the review and linked to the in-vitro/in-vivo response to these treatments. The literature review itself is preceded by a more general overview on cell communication, giving useful insights on how surface modification strategies should be developed.

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Porous polymer scaffolds surface‐modified with arginine‐glycine‐aspartic acid enhance bone cell attachment and differentiation in vitro

Cited by 159 publications

References 22 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

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