Porous Silicon Carrier Delivery System for Curcumin: Preparation, Characterization, and Cytotoxicity in Vitro

Abstract

A novel carrier delivery system for curcumin based on porous silicon (pSi) has been developed. The pSi film was prepared by electrochemical etching method and the microparticles of pSi were obtained by ultrasonication. The pSi film and particles of pSi were characterized by scanning electron microscopy (SEM). Sodium nitrite can induce curcumin into pSi and improve the drug loading (DL) and encapsulation efficiency (EE) of curcumin in double-distilled water loading buffer solution. Curcumin on the pSi surface was confirmed by Fourier transform infrared spectroscopy (FTIR) and UV-spectroscopy. The optimal loading conditions of curcumin in pSi are investigated. The curcumin in pSi keeps more than 95% bioactivity for 3 h and good repeatability. The cumulative release ratio of curcumin from PSi can reach 35% after 10 h. The in vitro cytotoxicity of curcumin loaded pSi was evaluated with HT-29 and NCM460 cell lines. The pSi delivery carrier can provide a controlled release and efficacy system for curcumin.

Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies

“…The curcumin loaded porous silica tested in HT-29 and NCM460 cells. The cell viability was reported to be 50% at a low concentration of 50 µg/mL or 0.05 mg/mL [ 55 ], and at this concentration the present UCNP-PLGA-nanocurcumin showed more than 60% cell viability. The nanocurcumin loaded UCNP-PLGA nanocomplexes showed moderate cytotoxicity ( Figure 7 ) against the rat glioma C6 cells compared to drug free UCNPs.…”

High-Resolution Cryo-Electron Microscopy Reveals the Unique Striated Hollow Structure of Photocatalytic Macrocyclic Polydiacetylene Nanotubes

“…43 Due to the hydrophobicity of curcumin, its delivery to physiological targets requires integration within carrier systems such as micelles, 44 cyclodextrins, 45 or porous nanoparticles. 46 The fluorescence spectroscopy data in Figure 3a indicate substantial uptake of curcumin by the MDA-1 nanotubes. In water, curcumin undergoes hydrophobicity-driven aggregation, resulting in significant quenching of its fluorescence signal 47 corresponding to the broad low-intensity peak at around 560 nm (black spectrum, Figure 3a).…”

Rapid Indomethacin Release from Porous Pectin Particles as a Colon-Targeted Drug Delivery System

“…To address these problems, many different carriers and drug delivery systems have been investigated. As part of these efforts, nanostructured particles have emerged as potential novel drug carriers owing to their high specific surface area, high porosity, low density, hybrid functionalities, and ease of handling. − Notably, among the various nanostructured particles, porous particles have been commonly used for oral administration. , Porous particles are made to improve stability, reduce side effects, alter drug release profiles, and efficiently deliver a pharmaceutically active ingredient at a low dose. − Many conventional delivery systems necessitate the incorporation of high concentrations of active agents for therapeutic success owing to their low efficiency . Thus, there is a need for delivery systems that can maximize the release period and efficiency of an active ingredient.…”