Porous silicon microneedle patches for delivery of polymyxin‐based antimicrobials

Tabassum, Nazia; Rudd, David; Yan, Li; Voelcker, Nicolas H.; Alba, Maria

doi:10.1002/nano.202300116

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Voelcker, Alba and colleagues, developed porous silicon microneedle patches to deliver polymycin B to the skin to treat bacterial infections [28]. After loading the drug into the porous layer, the authors demonstrated the antibacterial activity of the porous silicon microneedles against Gram-negative Escherichia coli and their potential for antimicrobial applications using the transdermal drug delivery approach.…”

Section: Areas Covered In the Special Topicmentioning

confidence: 99%

Special Issue on Advances in Porous Materials

Santos

2024

Nano Select

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This Special Issue is dedicated to current research activities on Advanced Porous Materials within the framework of “The NETPORE COST Action,” providing a collection of 12 outstanding contributions (four review papers and eight original research papers) from diverse research groups on the latest progresses regarding porous nano‐ and micro‐materials for diverse applications. The contributions herein address the impact of porous materials in basic science, batteries, biosensing, and translational and personalized medicine for the treatment of various diseases. Overall, this Special Issue is expected to provide important background and new knowledge on the latest advances in porous materials and their broad applications.

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Section: Areas Covered In the Special Topicmentioning

confidence: 99%

Special Issue on Advances in Porous Materials

Santos

2024

Nano Select

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Effect of Zr Doping on Structure and Ferroelectric Properties of Nanostructured Barium Titanate

Salem,

Altarawneh,

Alibwaini

et al. 2024

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Using soft chemistry methods, solid solutions of BaTi1‐xZrxO3 with 0 ≤ x ≤ 1 were obtained. The phase nature and features of the perovskite crystalline structure were established by x‐ray analysis and Fourier transform infrared (FTIR) spectroscopy. It was found that the average particle size increases with increasing content of zirconium cations. The average size of the crystallites, which are mostly irregular in shape and closely connected, is ∼43 nm. The d33 piezoelectric coefficient decreases while the concentration of zirconium cations increases. It is interesting to note that the residual polarization very strongly depends on the average crystallite size and, on the contrary, increases with increasing concentration of zirconium cations. The discovered behavior can be used in the design and production of electrostatic read‐only memory devices.

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Focused ion beam (FIB) prepared microtextured microneedle array capable of delivering drugs through punctured skin

Zhang,

Chen,

et al. 2024

Sci Rep

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Microtextured microneedles are tiny needle-like structures with micron-scale microtextures, and the drugs stored in the microtextures can be released after entering the skin to achieve the effect of precise drug delivery. In this study, the skin substitution model of Ogden’s hyperelastic model and the microneedle array and microtexture models with different geometrical parameters were selected to simulate and analyse the flow of the microtexture microneedle arrays penetrating the skin by the finite-element method, and the length of the microneedles was determined to be 200 μm, the width 160 μm, and the value of the gaps was determined to be 420 μm. A four-pronged cone was chosen as the shape of microneedles, and a rectangle was chosen as the shape of the drug-carrying microneedle. The initial microneedle arrays were prepared by wet etching using monocrystalline silicon as the material due to its high mechanical strength, stability and good biocompatibility. The sputtering yield, energy loss and material damage of single crystal silicon materials during focused ion beam (FIB) processing were calculated using Monte Carlo method and found to have optimum removal efficiency and processing accuracy at 30 keV ion beam voltage. After the initial microneedle arrays were prepared using wet etching, microtextures were prepared on the microneedles with 30° inclination and 45° inclination using FIB technique with processing parameters of 30 keV and 60 nA. Biocompatibility tests showed a cell survival rate of 99.42% for the cell set containing the microneedle array, indicating that the microneedle array was non-toxic to the cells. The viscosity and contact angle of 5-fluorouracil, triamcinolone acetonide and tacrolimus were examined and it was learnt that tacrolimus had the highest viscosity and the lowest contact angle and the configured solution was able to be more present in the microtexture and was more stable and less susceptible to loss. The experiments of drug-carrying skin puncture mice showed that the stained area of tacrolimus was brighter and more uniformly distributed, the stained area of microtextured microneedles was larger than that of ordinary microneedles by 70.52%, the drug-carrying area was larger than the average area of ordinary microneedles by 105.09%, and the drug-carrying effect of microtextured microneedles with a horizontal inclination angle of 30° was more effective.

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Porous silicon microneedle patches for delivery of polymyxin‐based antimicrobials

Cited by 3 publications

References 57 publications

Special Issue on Advances in Porous Materials

Special Issue on Advances in Porous Materials

Effect of Zr Doping on Structure and Ferroelectric Properties of Nanostructured Barium Titanate

Focused ion beam (FIB) prepared microtextured microneedle array capable of delivering drugs through punctured skin

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